CAJ | 학술논문

将经典维生素 B1法安息香缩合反应改进在惰性气体保护下进行，且在反应完成后加入硫代硫酸钠和锌粉抑制产物分解，可制备过去主要依赖 KCN 等剧毒催化剂合成的吸电子基团取代的苯偶姻衍生物。推测经典维生素 B1法分离不到产物，可能是由于柱层析时硅胶或氧化铝与维生素 B1分解产物的共同作用导致贫电子苯偶姻产物的分解，而 Zn-Na2 S2 O3溶液可以抑制这种作用。
장경전유생소 B1법안식향축합반응개진재타성기체보호하진행，차재반응완성후가입류대류산납화자분억제산물분해，가제비과거주요의뢰 KCN 등극독최화제합성적흡전자기단취대적분우인연생물。추측경전유생소 B1법분리불도산물，가능시유우주층석시규효혹양화려여유생소 B1분해산물적공동작용도치빈전자분우인산물적분해，이 Zn-Na2 S2 O3용액가이억제저충작용。
The Benzoins condensation reaction by the way of the classical Vitamin B1 is substituted under the protection of inert gases and adds aqueous Na2 S2 O3 and zinc dust after its completion to inhibit product disintegration to make thiamin derivate which is replaced by electron-withdrawing groups depended upon KCN hyper toxic catalyst synthesis.It is supposed that the classical way of Vitamin B1 segregated nothing and electron-deficient benzoins could not be prepared by classical Vitamin B1 -promoted ones might be owing to the synergy between silica gel /alumina and decomposed Vitamin B1 during column chromatography,which could be inhibited by Zn-Na2 S2 O3 .