临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
6期
1075-1079
,共5页
陈相军%吴青霞%陈敏%刘芳%李念
陳相軍%吳青霞%陳敏%劉芳%李唸
진상군%오청하%진민%류방%리념
白介素-35%癌症%外周血%Meta分析
白介素-35%癌癥%外週血%Meta分析
백개소-35%암증%외주혈%Meta분석
interleukin-35%cancer%circulation%Meta-analysis
目的:评价外周血白介素–35水平与肿瘤危险的相关性。方法:计算机检索PubMed、MEDLINE、EMBASE、CNKI和万方等数据库,检索2015年1月15日以前公开发表的文献。采用RevMan5.2.2分析软件对其进行分析和评价。结果:通过检索,最终纳入5篇研究。Meta分析结果显示外周血白介素–35浓度在癌症患者和正常组之间无明显差别(MD =41.91;95% CI,?6.33~90.15;P=0.09)。亚组分析也表明IL-35在白血病或其他癌症与正常对照组之间并无显著差异(MD =23.73;95% CI,?15.63~63.09;P=0.24);(MD =60.00;95% CI,?57.86~177.87;P=0.32)。性别研究分析表明,男性癌症患者中的外周血IL-35浓度与女性患者之间并无显著差异(MD =?3.25,95% CI,?8.39~1.88;P=0.21)。外周血IL-35在癌症淋巴结转移和无淋巴结转移病人中存在显著差异(MD =?23.18,95% CI,?37.93~?8.43, P=0.002)。结论:外周血IL-35浓度在癌症病人中并无显著相关性,但是可以作为癌症淋巴结转移有无的一个预测指标。
目的:評價外週血白介素–35水平與腫瘤危險的相關性。方法:計算機檢索PubMed、MEDLINE、EMBASE、CNKI和萬方等數據庫,檢索2015年1月15日以前公開髮錶的文獻。採用RevMan5.2.2分析軟件對其進行分析和評價。結果:通過檢索,最終納入5篇研究。Meta分析結果顯示外週血白介素–35濃度在癌癥患者和正常組之間無明顯差彆(MD =41.91;95% CI,?6.33~90.15;P=0.09)。亞組分析也錶明IL-35在白血病或其他癌癥與正常對照組之間併無顯著差異(MD =23.73;95% CI,?15.63~63.09;P=0.24);(MD =60.00;95% CI,?57.86~177.87;P=0.32)。性彆研究分析錶明,男性癌癥患者中的外週血IL-35濃度與女性患者之間併無顯著差異(MD =?3.25,95% CI,?8.39~1.88;P=0.21)。外週血IL-35在癌癥淋巴結轉移和無淋巴結轉移病人中存在顯著差異(MD =?23.18,95% CI,?37.93~?8.43, P=0.002)。結論:外週血IL-35濃度在癌癥病人中併無顯著相關性,但是可以作為癌癥淋巴結轉移有無的一箇預測指標。
목적:평개외주혈백개소–35수평여종류위험적상관성。방법:계산궤검색PubMed、MEDLINE、EMBASE、CNKI화만방등수거고,검색2015년1월15일이전공개발표적문헌。채용RevMan5.2.2분석연건대기진행분석화평개。결과:통과검색,최종납입5편연구。Meta분석결과현시외주혈백개소–35농도재암증환자화정상조지간무명현차별(MD =41.91;95% CI,?6.33~90.15;P=0.09)。아조분석야표명IL-35재백혈병혹기타암증여정상대조조지간병무현저차이(MD =23.73;95% CI,?15.63~63.09;P=0.24);(MD =60.00;95% CI,?57.86~177.87;P=0.32)。성별연구분석표명,남성암증환자중적외주혈IL-35농도여녀성환자지간병무현저차이(MD =?3.25,95% CI,?8.39~1.88;P=0.21)。외주혈IL-35재암증림파결전이화무림파결전이병인중존재현저차이(MD =?23.18,95% CI,?37.93~?8.43, P=0.002)。결론:외주혈IL-35농도재암증병인중병무현저상관성,단시가이작위암증림파결전이유무적일개예측지표。
Objective: To review systematically the association of circulation interleukin 35 (IL-35) with cancer risk. Methods: hTe databases of PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure (CNKI) and WangFang up to Jan 15, 2015 were searched for relevant articles. Meta-analysis was conducted using RevMan 5.2.2 sotfware.Results: Total ifve studies were ifnally included into this meta-analysis. hTe results of meta-analysis shown that no association of circulation IL-35 level between cancer patients and controls (MD =41.91; 95% CI,?6.33~90.15;P=0.09). Subgroups analysis also shown that there were no signiifcantly differences on IL-35 level between leukemia or other cancers and controls (MD =23.73, 95% CI,?15.63~63.09;P=0.24; MD =60.00, 95% CI,?57.86~177.87;P=0.32; respectively). Moreover, no associated to IL-35 between male and female patients (MD =?3.25, 95% CI,?8.39~1.88, P=0.21). However, there was a signiifcantly difference on association between lymph node metastasis and no-lymph node metastasis (MD =?23.18, 95% CI,?37.93~?8.43,P=0.002).Conclusion:No association between cancer patients and controls, but it can be as a predictor for lymph node metastasis patients.