CAJ | 학술논문

目的：观察辛伐他汀与替格瑞洛联用后对相互的临床疗效是否存在影响。方法：将急性冠脉综合征患者随机分为单用辛伐他汀组、单用替格瑞洛组及两药联合应用组，测定各组患者血清尿酸、转氨酶、肌酸激酶、血小板聚集率、血脂水平等，比较在临床疗效上是否存在相互影响。结果：与单用辛伐他汀组、单用替格瑞洛组比较，联合用药组在抗血小板聚集率及血脂水平等方面的差异均无统计学意义（P＞0．05）。结论：尽管研究显示辛伐他汀、替格瑞洛存在CYP3A4的竞争性抑制，药动学方面有一定影响，但短期各自的临床疗效改变不显著。
목적：관찰신벌타정여체격서락련용후대상호적림상료효시부존재영향。방법：장급성관맥종합정환자수궤분위단용신벌타정조、단용체격서락조급량약연합응용조，측정각조환자혈청뇨산、전안매、기산격매、혈소판취집솔、혈지수평등，비교재림상료효상시부존재상호영향。결과：여단용신벌타정조、단용체격서락조비교，연합용약조재항혈소판취집솔급혈지수평등방면적차이균무통계학의의（P＞0．05）。결론：진관연구현시신벌타정、체격서락존재CYP3A4적경쟁성억제，약동학방면유일정영향，단단기각자적림상료효개변불현저。
OBJECTIVE:To evaluate the efficacy of simvastatin and ticagrelor either alone or in combination for acute coronary syndrome.METHODS: The patients with acute coronary syndrome were assigned to receive either simvastatin or ticagrelor alone or simvastatin plus ticagrelor.The uric acid, creatine kinase, low density lipoprotein-cholesterol, aspartate transaminase and the rate of platelet aggregation were measured and the efficacy of simvastatin and Ticagrelor either alone or in combination were compared.RESULTS:There were no significant differences between the combination group and simvastatin group or ticagrelor group in the anti-platelet aggregation rate and blood lipid levels (P>0.05).CONCLUSIONS: Studies have shown competitive inhibition of CYP3A4 between simvastatin and ticagrelor, resulting in certain influence on the pharmacokinetics, however, their clinical efficacy showed no significant change in the short term when used in combination.