CAJ | 학술논문

目的：研究和探讨系统性红斑狼疮(systemic lupus erythematosus，SLE)患者尿白蛋白肌酐比值、肾小球滤过率(glomerular filtrationrate，GFR)水平情况及其与肾损害病变程度的关系，以期为临床诊治提供可靠依据。方法：入选2010年6月至2013年12月就诊于我院的SLE患者68例作为观察对象，将入选患者分为初治患者组37例和复治患者组31例，入院进行尿白蛋白肌酐比值、GFR检测，观察尿白蛋白肌酐比值、GFR在早期肾损害中的敏感性，同时通过其与病变程度的相关性研究进一步了解其临床意义和价值。结果：尿常规显示尿蛋白阳性患者为27例，阳性率为39.7%；24 h尿白蛋白肌酐比值检测结果升高患者31例(45.6%)；而GFR检测降低为46例，检出率为67.6%，差异具有显著性(P<0.05)，检查两组患者尿白蛋白肌酐比值、GFR，发现初治患者组尿白蛋白肌酐比值显著低于复治患者组，初治患者组GFR水平显著高于复治患者组(P<0.05)。说明尿白蛋白肌酐比值、GFR检出率明显高于尿常规；其中复治患者组尿白蛋白阳性率、尿白蛋白肌酐比值升高率、GFR降低检测率明显高于初治患者组，说明尿白蛋白肌酐比值、GFR检测有助于提示早期肾损害，并且有利于提示肾损害的活动性和疾病程度。结论：针对SLE患者进行2尿白蛋白肌酐比值、GFR检测有助于早期发现肾损害，并且对患者疾病的活动度和严重性的临床判断有指导性意义，值得临床推广应用。
목적：연구화탐토계통성홍반랑창(systemic lupus erythematosus，SLE)환자뇨백단백기항비치、신소구려과솔(glomerular filtrationrate，GFR)수평정황급기여신손해병변정도적관계，이기위림상진치제공가고의거。방법：입선2010년6월지2013년12월취진우아원적SLE환자68례작위관찰대상，장입선환자분위초치환자조37례화복치환자조31례，입원진행뇨백단백기항비치、GFR검측，관찰뇨백단백기항비치、GFR재조기신손해중적민감성，동시통과기여병변정도적상관성연구진일보료해기림상의의화개치。결과：뇨상규현시뇨단백양성환자위27례，양성솔위39.7%；24 h뇨백단백기항비치검측결과승고환자31례(45.6%)；이GFR검측강저위46례，검출솔위67.6%，차이구유현저성(P<0.05)，검사량조환자뇨백단백기항비치、GFR，발현초치환자조뇨백단백기항비치현저저우복치환자조，초치환자조GFR수평현저고우복치환자조(P<0.05)。설명뇨백단백기항비치、GFR검출솔명현고우뇨상규；기중복치환자조뇨백단백양성솔、뇨백단백기항비치승고솔、GFR강저검측솔명현고우초치환자조，설명뇨백단백기항비치、GFR검측유조우제시조기신손해，병차유리우제시신손해적활동성화질병정도。결론：침대SLE환자진행2뇨백단백기항비치、GFR검측유조우조기발현신손해，병차대환자질병적활동도화엄중성적림상판단유지도성의의，치득림상추엄응용。
Objective: To study and explore the systemic lupus erythematosus (SLE) patients with urinary albumin/creatinine ratio, glomerular filtrationrate (GFR) level and the severity of kidney damage, in order to provide a reliable basis for clinical diagnosis and treatment.Methods: Selected in 2010 June to 2013 year in December in ourhospital for treatment of systemic lupus erythematosus patients 68 cases as the observation object, all the patients were divided into treatment group of 37 cases and retreatment of patients in group of 31 patients, admitted to the hospital for urine albumin creatinine ratio, GFR testing, observation of urinary albumin creatinine ratio value, the sensitivity of GFR in diagnosis of early renal at the same time, through the study of damage, its correlation with the severity of the further understanding of the clinical signiifcance and value.Results:hTe results showed that patients with positive urine protein urine of 27 cases, the positive rate was 39.7%; the detection results of 24 h urinary albumin creatinine ratio increased in 31 cases (45.6%); and GFR detection is reduced to 46 cases, the detection rate was 67.6%, the difference was signiifcant (P<0.05), two groups were examined with urine protein to creatinine ratio, GFR, that was signiifcantly lower than that of patients with initial treatment group was signiifcantly higher than that of urine albumin creatinine ratio, retreatment patients newly diagnosed GFR patients group (P<0.05). Description of urinary albumin to creatinine ratio, the detection rate of GFR was signiifcantly higher than that of urine; the positive rate of patients with re treatment of urinary albumin, urinary albumin creatinine ratio increased, GFR decreased the detection rate was signiifcantly higher than that of untreated patients, illustrate the urinary albumin creatinine ratio, the detection of GFR is helpful to the early renal damage, and is beneifcial to renal damage the activity and the extent of the disease.Conclusion: For the patients with systemic lupus erythematosus (SLE) patients, 2 urinary albumin creatinine ratio and detection of GFR is helpful in the early diagnosis of renal damage and clinical judgment, activity and severity of disease has guiding signiifcance, is worthy of clinical application.