中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
6期
730-731,732
,共3页
郑志高%陈毅德%洪东花%林雨标%郑文慧
鄭誌高%陳毅德%洪東花%林雨標%鄭文慧
정지고%진의덕%홍동화%림우표%정문혜
药物疗法/副作用%周围神经系统疾病/药物疗法%硫辛酸%甲钴胺
藥物療法/副作用%週圍神經繫統疾病/藥物療法%硫辛痠%甲鈷胺
약물요법/부작용%주위신경계통질병/약물요법%류신산%갑고알
Drug therapy/adverse effects%Peripheral nervous system diseases/drug therapy%Thioctic acid%Mecobalamine
目的：观察硫辛酸联合甲钴胺治疗化疗药所致周围神经病变的疗效。方法：将126例恶性肿瘤化疗后周围神经病变患者随机分为治疗组和对照组，每组63例。治疗组给予α－硫辛酸600 mg静脉滴注、1日1次，甲钴胺500μg，静脉注射、1日1次；对照组单用甲钴胺500μg，静脉注射、1日1次，疗程均为2周。比较2组患者治疗前后临床疗效。结果：治疗组患者总有效率为80．95％（51／63），对照组为47．62％（30／63），治疗组优于对照组，差异有统计学意义（P＜0．05）。结论：α－硫辛酸联合甲钴胺治疗化疗药引起周围神经病变安全、有效。
目的：觀察硫辛痠聯閤甲鈷胺治療化療藥所緻週圍神經病變的療效。方法：將126例噁性腫瘤化療後週圍神經病變患者隨機分為治療組和對照組，每組63例。治療組給予α－硫辛痠600 mg靜脈滴註、1日1次，甲鈷胺500μg，靜脈註射、1日1次；對照組單用甲鈷胺500μg，靜脈註射、1日1次，療程均為2週。比較2組患者治療前後臨床療效。結果：治療組患者總有效率為80．95％（51／63），對照組為47．62％（30／63），治療組優于對照組，差異有統計學意義（P＜0．05）。結論：α－硫辛痠聯閤甲鈷胺治療化療藥引起週圍神經病變安全、有效。
목적：관찰류신산연합갑고알치료화료약소치주위신경병변적료효。방법：장126례악성종류화료후주위신경병변환자수궤분위치료조화대조조，매조63례。치료조급여α－류신산600 mg정맥적주、1일1차，갑고알500μg，정맥주사、1일1차；대조조단용갑고알500μg，정맥주사、1일1차，료정균위2주。비교2조환자치료전후림상료효。결과：치료조환자총유효솔위80．95％（51／63），대조조위47．62％（30／63），치료조우우대조조，차이유통계학의의（P＜0．05）。결론：α－류신산연합갑고알치료화료약인기주위신경병변안전、유효。
OBJECTIVE:To evaluate the clinical efficacy of α-lipoic acid plus mecobalamin for peripheral neuropathy induced by chemotherapy.METHODS:One hundred and tweenty six patients with chemotherapy-induced peripheral neuropathy were randomly divided into two groups ( of 63 cases each) to be treated with eitherα-lipoic acid (600 mg) q.d by intravenous infusion plus mecobalamin (500 μg) q.d by intravenous injection ( treatment groups) or with mecobalamin (500μg) q.d by intravenous infusion ( control group) for 2 weeks, the clinical efficacy between the two groups were compared.RESULTS: The response rate in the treatment group was better than in the control gorup [ 80.95%( 51/63 ) vs.47.62%( 30/63 ) , P <0.05 ] . CONCLUSIONS: α-Lipoic acid combined with mecobalamin are safe and effective in the treatment of peripheral neuropathy induced by chemotherapy.
