中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
6期
725-726,727
,共3页
利巴韦林气雾剂%施保利通片%疱疹性咽峡炎
利巴韋林氣霧劑%施保利通片%皰疹性嚥峽炎
리파위림기무제%시보리통편%포진성인협염
Ribavirin aerosol%Esberitox tablets%Herpangina
目的：观察利巴韦林气雾剂与施保利通片联合治疗小儿疱疹性咽峡炎的临床疗效。方法：选取儿科门诊2013年5月—2014年8月收治的疱疹性咽峡炎患儿135例，以随机数字表法分为治疗组（69例）和对照组（66例）。治疗组患儿给予利巴韦林气雾剂与施保利通片联合治疗，对照组患儿给予利巴韦林气雾剂单药治疗。2组患儿均给予退热等对症处理，合并细菌感染者加用头孢克洛干混悬剂。观察2组患儿退热时间，症状消失、疱疹消失时间，对比2组患儿的临床疗效。结果：治疗组患儿的总有效率（98．55％，68／69）明显高于对照组（84．85％，56／66）（P＜0．05），差异有统计学意义；治疗组患儿的退热时间、平均中位疱疹结痂时间及平均中位疱疹痊愈时间均明显优于对照组，差异有统计学意义（ P＜0．01）。2组患儿均未出现与药物有关的不良反应。结论：利巴韦林气雾剂联合施保利通片治疗小儿疱疹性咽峡炎，能较快改善患儿的临床症状及体征，疗程短、疗效明显，未见明显不良反应，值得临床推广。
目的：觀察利巴韋林氣霧劑與施保利通片聯閤治療小兒皰疹性嚥峽炎的臨床療效。方法：選取兒科門診2013年5月—2014年8月收治的皰疹性嚥峽炎患兒135例，以隨機數字錶法分為治療組（69例）和對照組（66例）。治療組患兒給予利巴韋林氣霧劑與施保利通片聯閤治療，對照組患兒給予利巴韋林氣霧劑單藥治療。2組患兒均給予退熱等對癥處理，閤併細菌感染者加用頭孢剋洛榦混懸劑。觀察2組患兒退熱時間，癥狀消失、皰疹消失時間，對比2組患兒的臨床療效。結果：治療組患兒的總有效率（98．55％，68／69）明顯高于對照組（84．85％，56／66）（P＜0．05），差異有統計學意義；治療組患兒的退熱時間、平均中位皰疹結痂時間及平均中位皰疹痊愈時間均明顯優于對照組，差異有統計學意義（ P＜0．01）。2組患兒均未齣現與藥物有關的不良反應。結論：利巴韋林氣霧劑聯閤施保利通片治療小兒皰疹性嚥峽炎，能較快改善患兒的臨床癥狀及體徵，療程短、療效明顯，未見明顯不良反應，值得臨床推廣。
목적：관찰리파위림기무제여시보리통편연합치료소인포진성인협염적림상료효。방법：선취인과문진2013년5월—2014년8월수치적포진성인협염환인135례，이수궤수자표법분위치료조（69례）화대조조（66례）。치료조환인급여리파위림기무제여시보리통편연합치료，대조조환인급여리파위림기무제단약치료。2조환인균급여퇴열등대증처리，합병세균감염자가용두포극락간혼현제。관찰2조환인퇴열시간，증상소실、포진소실시간，대비2조환인적림상료효。결과：치료조환인적총유효솔（98．55％，68／69）명현고우대조조（84．85％，56／66）（P＜0．05），차이유통계학의의；치료조환인적퇴열시간、평균중위포진결가시간급평균중위포진전유시간균명현우우대조조，차이유통계학의의（ P＜0．01）。2조환인균미출현여약물유관적불량반응。결론：리파위림기무제연합시보리통편치료소인포진성인협염，능교쾌개선환인적림상증상급체정，료정단、료효명현，미견명현불량반응，치득림상추엄。
OBJECTIVE:To evaluate the clinical efficacy of ribavirin aerosol combined with esberitox tablets for treatment of Children's herpangina. METHODS: A total of 135 children with herpangina in pediatric outpatient department from May 2013 to August 2014 were randomly divided into two groups.69 cases in the treatment group were given esberitox combined with ribavirin aerosol, and anther 66 cases in the control group were given ribavirin aerosol alone.Furthermore, both of the two groups were also given symptomatic treatment such as pyretolysis medication etc, and the patients with associated bacteria infection were also given cefaclor dry suspension.We recorded the time to fever clearance, symptom elimination and herpes elimination in two groups for evaluation of therapeutic efficacy.RESULTS:The total effective rate of treatment group(98.55%,68/69) was significantly higher than in the control group(84.85%, 56/66)(P<0.05).The treatment group was significantly better than the control group in terms of fever clearance time, mean median crusting time and mean median cure time of herpes ( P <0.01 ) .Neither groups showed adverse drug reactions.CONCLUSIONS:Treatment of children with herpangina using ribavirin aerosol combined with esberitox tablets resulted in rapid improvement in clinical symptoms and signs, short course of treatment, excellent efficacy and no adverse drug reaction, the use of the combination therapy is thus worthy of clinical promotion.
