CAJ | 학술논문

以弗氏链霉菌（ Streptomyces fradiae ） TP－116菌株作为出发菌株，采用紫外线、氯化锂和微波三重复合诱变，通过泰乐菌素抗性定向筛选，获得一株高产菌株YBT－06，并对其进行了遗传稳定性试验，结果表明突变株YBT－06生产代谢旺盛，遗传稳定性好，发酵效价比出发菌株提高了25％，达到11066μg／mL。
이불씨련매균（ Streptomyces fradiae ） TP－116균주작위출발균주，채용자외선、록화리화미파삼중복합유변，통과태악균소항성정향사선，획득일주고산균주YBT－06，병대기진행료유전은정성시험，결과표명돌변주YBT－06생산대사왕성，유전은정성호，발효효개비출발균주제고료25％，체도11066μg／mL。
Taking TP-116 strain of Streptomyces fradiae as a starting strain , using UV, lithium chloride and microwave triple compound mutagenesis , a high yield strainYBT-06 was got through the resistance of tylosin directional selection .The results on the genetic stability test showed that the mutant strain YBT -06 production metabolism exuberant , genetic stability was good , fermentation effect price had improved 25%than starting strains , reached 11066 μg/mL.