中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
5期
390-394
,共5页
张倩%万倩%孙丹%许文伟%关美萍%薛耀明
張倩%萬倩%孫丹%許文偉%關美萍%薛耀明
장천%만천%손단%허문위%관미평%설요명
糖尿病,2型%糖尿病肾脏疾病%非糖尿病肾脏疾病
糖尿病,2型%糖尿病腎髒疾病%非糖尿病腎髒疾病
당뇨병,2형%당뇨병신장질병%비당뇨병신장질병
Diabetes mellitus,type 2%Diabetic kidney disease%Non-diabetic renal disease
目的 探讨2型糖尿病合并糖尿病肾脏疾病的危险因素.方法 回顾分析930例住院2型糖尿病患者临床资料,根据不同肾小球滤过率与尿白蛋白水平以及是否合并糖尿病视网膜病变(DR)对患者进行分组比较.糖尿病肾脏疾病危险因素的分析采用二分类logistic回归分析法.结果 (1)随着肾小球滤过率的下降,2型糖尿病患者白蛋白尿患病率逐渐增加(P＜0.05).(2)22.26％的2型糖尿病患者合并糖尿病肾脏疾病,8.92％的患者合并非糖尿病肾脏疾病.糖尿病肾脏疾病组患者的病程、收缩压、血肌酐、尿白蛋白水平等显著高于非糖尿病肾脏疾病组患者,糖尿病肾脏疾病组患者的血红蛋白[(125.40±21.95对138.18±19.67)g/L]、血清白蛋白[(37.45±5.54对40.55±3.55)g/L]、肾小球滤过率[(89.66(59.10 ～ 108.25)对103.15(85.39～114.88)ml·min-1·(1.73m2)-1]显著低于非糖尿病肾脏疾病组患者,差异均有统计学意义(P＜0.05).(3) Logistic回归分析结果显示,年龄、糖尿病病程、收缩压、血尿酸、糖尿病视网膜病变及高血压病是糖尿病肾脏疾病发生的独立危险因素,血清白蛋白是其保护因素(均P＜0.01).结论 2型糖尿病患者合并糖尿病肾脏疾病与多种临床危险因素相关,积极控制血压、血尿酸,纠正低蛋白血症等有助于延缓糖尿病肾脏疾病的进展.
目的 探討2型糖尿病閤併糖尿病腎髒疾病的危險因素.方法 迴顧分析930例住院2型糖尿病患者臨床資料,根據不同腎小毬濾過率與尿白蛋白水平以及是否閤併糖尿病視網膜病變(DR)對患者進行分組比較.糖尿病腎髒疾病危險因素的分析採用二分類logistic迴歸分析法.結果 (1)隨著腎小毬濾過率的下降,2型糖尿病患者白蛋白尿患病率逐漸增加(P＜0.05).(2)22.26％的2型糖尿病患者閤併糖尿病腎髒疾病,8.92％的患者閤併非糖尿病腎髒疾病.糖尿病腎髒疾病組患者的病程、收縮壓、血肌酐、尿白蛋白水平等顯著高于非糖尿病腎髒疾病組患者,糖尿病腎髒疾病組患者的血紅蛋白[(125.40±21.95對138.18±19.67)g/L]、血清白蛋白[(37.45±5.54對40.55±3.55)g/L]、腎小毬濾過率[(89.66(59.10 ～ 108.25)對103.15(85.39～114.88)ml·min-1·(1.73m2)-1]顯著低于非糖尿病腎髒疾病組患者,差異均有統計學意義(P＜0.05).(3) Logistic迴歸分析結果顯示,年齡、糖尿病病程、收縮壓、血尿痠、糖尿病視網膜病變及高血壓病是糖尿病腎髒疾病髮生的獨立危險因素,血清白蛋白是其保護因素(均P＜0.01).結論 2型糖尿病患者閤併糖尿病腎髒疾病與多種臨床危險因素相關,積極控製血壓、血尿痠,糾正低蛋白血癥等有助于延緩糖尿病腎髒疾病的進展.
목적 탐토2형당뇨병합병당뇨병신장질병적위험인소.방법 회고분석930례주원2형당뇨병환자림상자료,근거불동신소구려과솔여뇨백단백수평이급시부합병당뇨병시망막병변(DR)대환자진행분조비교.당뇨병신장질병위험인소적분석채용이분류logistic회귀분석법.결과 (1)수착신소구려과솔적하강,2형당뇨병환자백단백뇨환병솔축점증가(P＜0.05).(2)22.26％적2형당뇨병환자합병당뇨병신장질병,8.92％적환자합병비당뇨병신장질병.당뇨병신장질병조환자적병정、수축압、혈기항、뇨백단백수평등현저고우비당뇨병신장질병조환자,당뇨병신장질병조환자적혈홍단백[(125.40±21.95대138.18±19.67)g/L]、혈청백단백[(37.45±5.54대40.55±3.55)g/L]、신소구려과솔[(89.66(59.10 ～ 108.25)대103.15(85.39～114.88)ml·min-1·(1.73m2)-1]현저저우비당뇨병신장질병조환자,차이균유통계학의의(P＜0.05).(3) Logistic회귀분석결과현시,년령、당뇨병병정、수축압、혈뇨산、당뇨병시망막병변급고혈압병시당뇨병신장질병발생적독립위험인소,혈청백단백시기보호인소(균P＜0.01).결론 2형당뇨병환자합병당뇨병신장질병여다충림상위험인소상관,적겁공제혈압、혈뇨산,규정저단백혈증등유조우연완당뇨병신장질병적진전.
Objective To analyze risk factors for diabetic kidney disease (DKD) in inpatients with type 2 diabetes.Methods A total of 930 inpatients with type 2 diabetes were enrolled in the study and grouped according to different levels of estimated glomerular filtration rate (eGFR),albuminuria,and diabetic retinopathy.Logistic regression analysis was adopted to explore the risk factors for DKD in inpatients with type 2 diabetes.Results (1) The prevalence of albuminuria in patients with type 2 diabetes mellitus was increased with declining eGFR (P ＜ 0.05).(2) The prevalences of DKD and non-diabetic renal disease (NDRD) in patients with type 2 diabetes mellitus were 22.26％ and 8.92％,respectively.Compared with patients with NDRD,patients with DKD had longer diabetic duration,higher levels of systolic blood pressure,serum creatinine,and urinary albumin excretion,and lower levels of hemoglobin[(125.40 ± 21.95 vs 138.18 ± 19.67) g/L],serum albumin[(37.45 ± 5.54 vs 40.55 ± 3.55) g/L],and eGFR[(89.66 (59.10-108.25) vs 103.15 (85.39-114.88) ml · min-1 · (1.73 m2)-1,all P＜0.05].(3) Logistic regression analysis showed that age,diabetic duration,systolic blood pressure,serum uric acid,diabetic retinopathy,and hypertension are the independent risk factors for diabetic kidney disease in inpatients with type 2 diabetes,while serum albumin was the protective factor (all P＜0.01).Conclusions A variety of clinic risk factors were associated with DKD.Better control of blood pressure,serum uric acid,and hypoalbuminemia should be performed to delay the progress of DKD.
