CAJ | 학술논문

糖尿病肾病(diabetic nephropapthy,DN)是导致终末期肾病的常见原因,早期诊断、及时治疗有助于延缓其进展.Smad蛋白是介导转化生长因子β超家族胞内信号转导途径的一组蛋白质.新近研究发现Smad1蛋白在DN肾纤维化过程中扮演重要角色.尿Smad1出现在DN早期阶段,有望成为早期诊断DN的非侵入性指标.
당뇨병신병(diabetic nephropapthy,DN)시도치종말기신병적상견원인,조기진단、급시치료유조우연완기진전.Smad단백시개도전화생장인자β초가족포내신호전도도경적일조단백질.신근연구발현Smad1단백재DN신섬유화과정중분연중요각색.뇨Smad1출현재DN조기계단,유망성위조기진단DN적비침입성지표.
Diabetic nephropapthy (DN) is a common cause of end-stage renal disease.Early diagnosis and treatment are significant for delaying the development of DN.Smad proteins mediate transforming growth factor β superfamily intracellular signal transduction.Recent studies have found that Smad1 protein plays an important role in the process of renal fibrosis.Urine Smad1 emerges in the early stage of DN,which is expected to be a non-invasive indicator in early diagnosis of DN.