CAJ | 학술논문

目的：比较奥氮平与利培酮治疗老年痴呆伴精神行为症状患者的疗效及安全性。方法将52例老年痴呆伴精神行为症状患者随机分为奥氮平组与利培酮组，分别予以奥氮平与利培酮治疗，观察8周。治疗前后采用痴呆病理行为评定量表、副反应量表评定临床疗效及不良反应。结果奥氮平组治疗第2周末起，利培酮组治疗第4周末起痴呆病理行为评定量表评分较治疗前显著降低（P＜0．01），治疗第2周末奥氮平组显著低于利培酮组（P＜0．05或0．01）；奥氮平组有效率为92．3％，利培酮组为88．5％，两组比较差异无显著性（ P＞0．05）；奥氮平组不良反应发生率显著低于利培酮组（P＜0．05）。结论奥氮平与利培酮治疗老年痴呆伴精神行为症状患者疗效显著且相当，但奥氮平起效更快，安全性更高。
목적：비교오담평여리배동치료노년치태반정신행위증상환자적료효급안전성。방법장52례노년치태반정신행위증상환자수궤분위오담평조여리배동조，분별여이오담평여리배동치료，관찰8주。치료전후채용치태병리행위평정량표、부반응량표평정림상료효급불량반응。결과오담평조치료제2주말기，리배동조치료제4주말기치태병리행위평정량표평분교치료전현저강저（P＜0．01），치료제2주말오담평조현저저우리배동조（P＜0．05혹0．01）；오담평조유효솔위92．3％，리배동조위88．5％，량조비교차이무현저성（ P＞0．05）；오담평조불량반응발생솔현저저우리배동조（P＜0．05）。결론오담평여리배동치료노년치태반정신행위증상환자료효현저차상당，단오담평기효경쾌，안전성경고。
Objective To compare the efficacy and safety between olanzapine and risperidone in senile de‐mentia with behavioral and psychological symptoms (BPS) .Methods Fifty‐two senile dementia patients with BPS were randomly assigned to olanzapine and risperidone group treated with olanzapine or risperi‐done for 8 weeks .Efficacies were assessed with the Rating Scale of the Behavioral Pathology in Alzheime‐r′s Disease (BEHAVE‐AD) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results The BEHAVE‐AD score lowered more significantly since the end of the 2nd week in olanzapine group and since the 4th in risperidone group compared with pretreatment (P<0 .01) , so did that in olanzapine than in risperidone group at the end of the 2nd week (P<0 .05 or 0 .01);effective rate was respectively 92 .3% in olanzapine and 88 .5% in risperidone group ,which showed no significant difference (P>0 .05);the incidence of adverse reactions was significantly lower in olanzapine than in ris‐peridone group (P<0 .05) .Conclusion Both olanzapine and risperidone have an equivalent and evident effect in senile dementia with BPS ,but the former takes effect more rapidly and has higher safety .