实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
5期
25-27
,共3页
卒中%凝血因子Ⅶ%基因多态性
卒中%凝血因子Ⅶ%基因多態性
졸중%응혈인자Ⅶ%기인다태성
Stroke%Coagulation factor Ⅶ%Gene polymorphism
目的:探究唐山地区汉族人群凝血因子Ⅶ(FⅦ)基因多态性与急性缺血性脑卒中的关系。方法选取2009年10月—2011年5月在河北联合大学附属医院急诊科住院的72例急性缺血性脑卒中患者作为观察组,另选取2009年10月—2011年10月在河北联合大学附属医院体检的健康者88例作为对照组。采用基因测序方法检测FⅦ基因R353Q(rs6046)位点多态性。比较两组受试者基因型和等位基因分布频率。结果两组受试者年龄、性别、吸烟率、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、血糖(GLU)比较,差异均无统计学意义(P>0.05)。基因测序见FⅦ基因扩增片段存在R353Q(rs6046)位点碱基转换突变(G→A),并发现2种基因型:纯合子RR,杂合子RQ。两组受试者FⅦ基因R353Q(rs6046)位点RR、RQ基因型及R、Q等位基因分布频率比较,差异无统计学意义(P>0.05)。结论唐山地区汉族人群FⅦ基因多态性与急性缺血性脑卒中无关。
目的:探究唐山地區漢族人群凝血因子Ⅶ(FⅦ)基因多態性與急性缺血性腦卒中的關繫。方法選取2009年10月—2011年5月在河北聯閤大學附屬醫院急診科住院的72例急性缺血性腦卒中患者作為觀察組,另選取2009年10月—2011年10月在河北聯閤大學附屬醫院體檢的健康者88例作為對照組。採用基因測序方法檢測FⅦ基因R353Q(rs6046)位點多態性。比較兩組受試者基因型和等位基因分佈頻率。結果兩組受試者年齡、性彆、吸煙率、總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、血糖(GLU)比較,差異均無統計學意義(P>0.05)。基因測序見FⅦ基因擴增片段存在R353Q(rs6046)位點堿基轉換突變(G→A),併髮現2種基因型:純閤子RR,雜閤子RQ。兩組受試者FⅦ基因R353Q(rs6046)位點RR、RQ基因型及R、Q等位基因分佈頻率比較,差異無統計學意義(P>0.05)。結論唐山地區漢族人群FⅦ基因多態性與急性缺血性腦卒中無關。
목적:탐구당산지구한족인군응혈인자Ⅶ(FⅦ)기인다태성여급성결혈성뇌졸중적관계。방법선취2009년10월—2011년5월재하북연합대학부속의원급진과주원적72례급성결혈성뇌졸중환자작위관찰조,령선취2009년10월—2011년10월재하북연합대학부속의원체검적건강자88례작위대조조。채용기인측서방법검측FⅦ기인R353Q(rs6046)위점다태성。비교량조수시자기인형화등위기인분포빈솔。결과량조수시자년령、성별、흡연솔、총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL-C)、혈당(GLU)비교,차이균무통계학의의(P>0.05)。기인측서견FⅦ기인확증편단존재R353Q(rs6046)위점감기전환돌변(G→A),병발현2충기인형:순합자RR,잡합자RQ。량조수시자FⅦ기인R353Q(rs6046)위점RR、RQ기인형급R、Q등위기인분포빈솔비교,차이무통계학의의(P>0.05)。결론당산지구한족인군FⅦ기인다태성여급성결혈성뇌졸중무관。
Objective To investigate the correlation between gene polymorphism of coagulation factor Ⅶ and acute ischemic stroke in Han population in Tangshan. Methods From October 2009 to May 2011 in the Department of Emergency, the Affiliated Hospital of Hebei United University,72 in-patients with acute ischemic stroke were selected as observation group;from October 2009 to October 2011 in the Affiliated Hospital of Hebei United University,88 healthy cases were selected as control group. Gene sequencing method was used to detect the polymorphism of coagulation factor Ⅶ gene R353Q(rs6046) locus,the gene types and allelic frequency were compared between the two groups. Results No statistically significant differences of age,gender,smoking rate,TC,TG,LDL-C,blood glucose was found between the two groups(P<0. 05). Gene sequencing result showed that,there was conversion mutation of G→A in coagulation factor Ⅶ gene R353Q(rs6046) locus,and two gene types were found:RR and RQ. No statistically significant differences of RR gene type,RQ gene type,R or Q allelic frequency was found between the two groups ( P >0. 05 ). Conclusion No correlation was found between gene polymorphism of coagulation factor Ⅶ and acute ischemic stroke in Han population in Tangshan.