CAJ | 학술논문

目的：探讨三酰甘油（ TG）和高密度脂蛋白胆固醇（ HDL-C）与脑出血的关系。方法选取2011年2月—2012年3月汕头市潮阳区大峰医院收治的脑疾病患者168例，其中脑出血患者112例（研究组），非脑出血患者56例（对照组），再将脑出血组患者按不同出血部位分为4个亚组，即基底核出血组54例、脑叶出血组27例、幕下出血组21例、脑室出血组10例。回顾性分析患者的一般资料（性别、年龄、心率、高血压史、吸烟史、酗酒史）、血脂指标〔总胆固醇（TC）、TG、低密度脂蛋白胆固醇（LDL-C）、HDL-C、载脂蛋白A1（ApoA1）、载脂蛋白B （ ApoB）〕，并分析其与脑出血的关系。结果两组患者性别、年龄、心率、TC、LDL-C、ApoA1水平比较，差异无统计学意义（P>0.05）；研究组患者高血压发生率、吸烟率、酗酒率、TG、ApoB水平高于对照组，HDL-C水平低于对照组（P<0.05）。多因素Logistic回归分析结果显示，男性、年龄>60岁、吸烟、酗酒、高血压、TG≥1.70 mmol/L、HDL-C<3.12 mmol/L是脑出血的危险因素（ P<0.05）。4亚组患者HDL-C水平比较，差异无统计学意义（ P>0.05）；脑叶出血组患者TG、TC及LDL-C水平均低于基底核出血组、幕下出血组及脑室出血组（P<0.05）。结论TG≥1.70 mmol/L、HDL-C<3.12 mmol/L是脑出血的危险因素，可作为临床筛查及诊断脑出血的参考指标。
목적：탐토삼선감유（ TG）화고밀도지단백담고순（ HDL-C）여뇌출혈적관계。방법선취2011년2월—2012년3월산두시조양구대봉의원수치적뇌질병환자168례，기중뇌출혈환자112례（연구조），비뇌출혈환자56례（대조조），재장뇌출혈조환자안불동출혈부위분위4개아조，즉기저핵출혈조54례、뇌협출혈조27례、막하출혈조21례、뇌실출혈조10례。회고성분석환자적일반자료（성별、년령、심솔、고혈압사、흡연사、후주사）、혈지지표〔총담고순（TC）、TG、저밀도지단백담고순（LDL-C）、HDL-C、재지단백A1（ApoA1）、재지단백B （ ApoB）〕，병분석기여뇌출혈적관계。결과량조환자성별、년령、심솔、TC、LDL-C、ApoA1수평비교，차이무통계학의의（P>0.05）；연구조환자고혈압발생솔、흡연솔、후주솔、TG、ApoB수평고우대조조，HDL-C수평저우대조조（P<0.05）。다인소Logistic회귀분석결과현시，남성、년령>60세、흡연、후주、고혈압、TG≥1.70 mmol/L、HDL-C<3.12 mmol/L시뇌출혈적위험인소（ P<0.05）。4아조환자HDL-C수평비교，차이무통계학의의（ P>0.05）；뇌협출혈조환자TG、TC급LDL-C수평균저우기저핵출혈조、막하출혈조급뇌실출혈조（P<0.05）。결론TG≥1.70 mmol/L、HDL-C<3.12 mmol/L시뇌출혈적위험인소，가작위림상사사급진단뇌출혈적삼고지표。
Objective To investigate the correlation between TG,HDL-C and cerebral hemorrhage. Methods From February 2011 to March 2012 in Dafeng Hospital of Chaoyang District,Shantou,a total of 168 patients with encephalopathy were selected,and they were divided into case group(with cerebral hemorrhage,n=112)and control group(without cerebral hemorrhage,n=56) according to the incidence of cerebral hemorrhage. According to hemorrhage positions,patients of case group were divided into four subgroups:A group with basal ganglia hemorrhage ( n = 54 ), B group with cerebral lobe hemorrhage(n=27),C group with lower tentorium hemorrhage(n=21),D group with cerebral ventricle hemorrhage(n=10). General information including gender,age,heart rate,hypertension history,smoking history,drinking history,blood lipids index including TC,TG,LDL-C,HDL-C,ApoA1,ApoB were retrospectively analyzed,and their correlations with cerebral hemorrhage were analyzed. Results No statistically significant differences of gender,age,heart rate,TC,LDL-C or ApoA1 was found between case group and control group ( P >0. 05 );while incidence of hypertension, smoking rate, drinking rate,TG and ApoB of case group were statistically significantly higher than those of control group,HDL-C of case group was statistically significantly lower than that of control group(P<0. 05). Multivariate Logistic regression analysis showed that,male,age>60 years old,smoking,drinking,hypertension,TG≥1. 70 mmol/L,HDL-C <3. 12 mmol/L were risk factors of cerebral hemorrhage ( P <0. 05 ). No statistically significant differences of HDL - C was found among the four subgroups(P>0. 05),while TG,TC and LDL-C of B group was statistically significantly lower than that of groups A,C,D, respectively(P<0. 05). Conclusion TG≥1. 70 mmol/L,HDL-C<3. 12 mmol/L are risk factors of cerebral hemorrhage, and can be used as screening or diagnostic index for cerebral hemorrhage.