CAJ | 학술논문

目的：观察荜澄茄不同极性提取物对豚鼠胆石症的干预作用。方法用致石饲料建立豚鼠胆结石模型，荜澄茄不同极性提取物灌胃给药，比较各组豚鼠的成石率，并检测血脂、胆汁成分等指标。结果荜澄茄醚提物1．2g·kg －1、醇提物1．7g·kg －1、水提物2．8g·kg－1、混合物2．55g·kg－1具有抑制豚鼠胆结石形成作用，增加胆结石豚鼠胆囊中的胆汁量。醚提物1．2g·kg －1可降低胆汁中的总胆红素和胆固醇含量，可降低Ca2＋的浓度；水提物2．8g·kg －1和混合物2．55g·kg －1可降低胆汁中胆固醇含量；醇提物1．7 g·kg －1可降低血液中胆固醇的含量；混合物2．55 g·kg －1可提高血液高密度脂蛋白。其中醚提物作用最强，醇提物其次。结论荜澄茄制剂可以作为胆囊炎、胆管炎和胆石症的治疗制剂。
목적：관찰필징가불동겁성제취물대돈서담석증적간예작용。방법용치석사료건립돈서담결석모형，필징가불동겁성제취물관위급약，비교각조돈서적성석솔，병검측혈지、담즙성분등지표。결과필징가미제물1．2g·kg －1、순제물1．7g·kg －1、수제물2．8g·kg－1、혼합물2．55g·kg－1구유억제돈서담결석형성작용，증가담결석돈서담낭중적담즙량。미제물1．2g·kg －1가강저담즙중적총담홍소화담고순함량，가강저Ca2＋적농도；수제물2．8g·kg －1화혼합물2．55g·kg －1가강저담즙중담고순함량；순제물1．7 g·kg －1가강저혈액중담고순적함량；혼합물2．55 g·kg －1가제고혈액고밀도지단백。기중미제물작용최강，순제물기차。결론필징가제제가이작위담낭염、담관염화담석증적치료제제。
Objective To investigate the effects of various Litseae f ructus extracts on experimental gallstone in guinea pigs .Method Gallstone guinea pigs model was established and different extracts were administered by ig ..The rate of gallstone formation and the indexes including plasma lipids and biliary component were measured and compared .Results The Litseae f ructus extracts with different polarity ,such as ether extract 1 .2 g · kg -1 ,alcoholic extract 1 .7 g · kg -1 ,water extract 2 .8 g · kg -1 ,and mixture 2 .55 g · kg -1 ,can inhibit the formation of gallstone in guinea pigs ,increase the amount of bile in the gallbladder .Ether extract 1 .2 g · kg -1 decreased the contents of T‐Bil and TC in bile ,and the concentration of Ca2+ .Water extract 2 .8 g · kg -1 and mix‐ture 2 .55 g · kg -1 decreased the contents of TC in bile .Alcoholic extract 1 .7 g · kg -1 decreased the contents of TC in blood . Mixture 2 .55 g · kg -1 increased the high density protein in blood .The effect of ether extract was the strongest and the next was the alcohol extract .Conclusion The Litseae f ructus extracts ,especially ether extracts ,could be used as therapeutic agents for cholecystitis ,cholangitis and cholelithiasis .