实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
5期
107-109,112
,共4页
脑损伤%高压氧%治疗结果%脑氧代谢
腦損傷%高壓氧%治療結果%腦氧代謝
뇌손상%고압양%치료결과%뇌양대사
Brain injuries%Hyperbaric oxygenation%Treatment outcome%Cerebral oxygen metabolism
目的：探讨高压氧辅助治疗重症脑创伤恢复期患者的临床效果及对脑氧代谢的影响。方法选取2011年2月—2014年2月湖北医药学院附属东风医院神经外科收治的重症脑创伤恢复期患者120例，随机分为治疗组和对照组，各60例。对照组患者给予常规治疗及对症治疗，治疗组患者在对照组基础上联合高压氧治疗；两组患者均治疗14 d。比较两组患者临床疗效，治疗前后炎性因子〔血清白介素6（ IL-6）和肿瘤坏死因子α（ TNF-α）水平〕、认知功能〔简易精神状况检查表（ MMSE ）评分、数字广度测验（ DST ）评分〕及脑氧代谢指标〔动脉血氧含量（ CaO2）和颈内静脉球部血氧含量（ CjvO2）〕。结果治疗组显效20例、有效38例、无效2例；对照组显效16例、有效34例、无效10例；治疗组患者临床疗效优于对照组（ P<0.05）。治疗前两组患者血清IL-6、TNF-α水平及MMSE评分、DST评分比较，差异无统计学意义（ P>0.05）；治疗后治疗组患者血清IL-6、TNF-α水平均低于对照组，MMSE评分、DST评分均高于对照组（ P<0.05）。治疗前后两组患者CaO2、CjvO2比较，差异无统计学意义（ P
目的：探討高壓氧輔助治療重癥腦創傷恢複期患者的臨床效果及對腦氧代謝的影響。方法選取2011年2月—2014年2月湖北醫藥學院附屬東風醫院神經外科收治的重癥腦創傷恢複期患者120例，隨機分為治療組和對照組，各60例。對照組患者給予常規治療及對癥治療，治療組患者在對照組基礎上聯閤高壓氧治療；兩組患者均治療14 d。比較兩組患者臨床療效，治療前後炎性因子〔血清白介素6（ IL-6）和腫瘤壞死因子α（ TNF-α）水平〕、認知功能〔簡易精神狀況檢查錶（ MMSE ）評分、數字廣度測驗（ DST ）評分〕及腦氧代謝指標〔動脈血氧含量（ CaO2）和頸內靜脈毬部血氧含量（ CjvO2）〕。結果治療組顯效20例、有效38例、無效2例；對照組顯效16例、有效34例、無效10例；治療組患者臨床療效優于對照組（ P<0.05）。治療前兩組患者血清IL-6、TNF-α水平及MMSE評分、DST評分比較，差異無統計學意義（ P>0.05）；治療後治療組患者血清IL-6、TNF-α水平均低于對照組，MMSE評分、DST評分均高于對照組（ P<0.05）。治療前後兩組患者CaO2、CjvO2比較，差異無統計學意義（ P
목적：탐토고압양보조치료중증뇌창상회복기환자적림상효과급대뇌양대사적영향。방법선취2011년2월—2014년2월호북의약학원부속동풍의원신경외과수치적중증뇌창상회복기환자120례，수궤분위치료조화대조조，각60례。대조조환자급여상규치료급대증치료，치료조환자재대조조기출상연합고압양치료；량조환자균치료14 d。비교량조환자림상료효，치료전후염성인자〔혈청백개소6（ IL-6）화종류배사인자α（ TNF-α）수평〕、인지공능〔간역정신상황검사표（ MMSE ）평분、수자엄도측험（ DST ）평분〕급뇌양대사지표〔동맥혈양함량（ CaO2）화경내정맥구부혈양함량（ CjvO2）〕。결과치료조현효20례、유효38례、무효2례；대조조현효16례、유효34례、무효10례；치료조환자림상료효우우대조조（ P<0.05）。치료전량조환자혈청IL-6、TNF-α수평급MMSE평분、DST평분비교，차이무통계학의의（ P>0.05）；치료후치료조환자혈청IL-6、TNF-α수평균저우대조조，MMSE평분、DST평분균고우대조조（ P<0.05）。치료전후량조환자CaO2、CjvO2비교，차이무통계학의의（ P
Objective To investigate the clinical effect of hyperbaric oxygenation on severe brain trauma at recovery phase and its impact on cerebral oxygen metabolism. Methods From February 2011 to February 2014,a total of 120 patients with severe brain trauma at recovery phase were selected in the Department of Neurosurgery,Dongfeng Hospital Affiliated to Hubei University of Medicine,and they were randomly divided into treatment group and control group,each of 60 cases. Patients of control group were given conventional treatment and symptomatic treatment,while patients of treatment group were given extra hyperbaric oxygenation based on conventional and symptomatic treatment,both groups treated for 14 days. Clinical effect,serum levels of IL-6 and TNF-α,MMSE score and DST score,cerebral oxygen metabolism index including CaO2 ,CjvO2 before and after treatment were compared between the two groups. Results In treatment group,20 cases got excellent effect,38 cases got good effect,2 cases were invalid;in control group,16 cases got excellent effect,34 cases got good effect,10 cases were invalid;the clinical effect of treatment group was statistically significantly better than that of control group ( P <0. 05 ). No statistically significant differences of serum levels of IL-6 or TNF-α,MMSE score or DST score was found between the two groups before treatment ( P >0. 05 );while after treatment, serum levels of IL -6 and TNF - α of treatment group were statistically significantly lower than those of control group,MMSE score and DST score of treatment group were statistically significantly higher than those of control group(P<0. 05). No statistically significant differences of CaO2 or CjvO2 was found between the two groups before or after treatment(P>0. 05). Conclusion Hyperbaric oxygenation can effectively improve the clinical effect of patients with severe brain trauma at recovery phase,inhibit the expression of inflammatory cytokines,is helpful to maintain stable cerebral oxygen metabolism and promote the recovery of neurological function.
