CAJ | 학술논문

目的：探讨不同药物治疗脑卒中后抑郁的临床效果及安全性。方法选取脑卒中后抑郁症患者183例，随机分为A、B 2组。A组95例，给予齐拉西酮治疗，B组88例，给予利培酮治疗。分别于治疗1周、2周、6周末时采用HAMD量表和HAMA量表对2组抑郁及焦虑程度进行评价，计算两项指标减分率，评价2组治疗效果；采用TESS量表对2组不良反应进行评价。结果治疗1周、2周和6周末2组HAMD减分率、HAMA减分率比较差异无统计学意义（P＞0.05）。2组痊愈率和有效率比较差异无统计学意义（P＞0.05）；治疗1周、2周和6周末2组 TESS得分比较差异有统计学意义（P＜0.05）。结论齐拉西酮与利培酮治疗脑卒中后抑郁患者疗效方面无明显差别，但齐拉西酮的不良反应更小，可作为首选药物应用。
목적：탐토불동약물치료뇌졸중후억욱적림상효과급안전성。방법선취뇌졸중후억욱증환자183례，수궤분위A、B 2조。A조95례，급여제랍서동치료，B조88례，급여리배동치료。분별우치료1주、2주、6주말시채용HAMD량표화HAMA량표대2조억욱급초필정도진행평개，계산량항지표감분솔，평개2조치료효과；채용TESS량표대2조불량반응진행평개。결과치료1주、2주화6주말2조HAMD감분솔、HAMA감분솔비교차이무통계학의의（P＞0.05）。2조전유솔화유효솔비교차이무통계학의의（P＞0.05）；치료1주、2주화6주말2조 TESS득분비교차이유통계학의의（P＜0.05）。결론제랍서동여리배동치료뇌졸중후억욱환자료효방면무명현차별，단제랍서동적불량반응경소，가작위수선약물응용。
Objective To investigate the clinical efficacy and safety of different drugs in treatment of post‐stroke depres‐sion.Methods 183 cases with post‐stroke depression were randomly divided into group A(n=95) and group B(n=88). Pa‐tients in group A received ziprasidone treatment ,group B received risperidone. After 1‐,2‐and 6‐week treatment ,we respec‐tively used the HAMD scale and HAMA scale to evaluate the situation of depression and anxiety in two groups ,and TESS scale was used to record adverse reactions. Results After 1‐,2‐and 6‐week treatment ,reduction rate of both HAMD scores and HAMA scores ,effective rate and cure rate in two groups showed no statistical difference (P>0.05);While there was sig‐nificant difference between two groups in terms of TESS scores (P<0.05). Conclusion Compared with risperidone ,ziprasi‐done has less adverse events with the no difference of therapeutic efficacy ,which can be considered as preferred drug for appli‐cation.