CAJ | 학술논문

目的：观察L PA水平表达，并对其临床意义进行分析。方法入选近年来就诊于荔湾区第二人民医院的妊娠期高血压患者90例作为观察A组，同期选取30例正常晚期妊娠妇女为观察B组，未孕健康妇女30例为对照组，分别检测LPA水平，探讨LPA和妊娠期高血压的关系；妊娠期高血压孕妇根据病情程度分为妊娠期高血压组、轻度子痫前期组和重度子痫前期组，比较3组LPA水平。结果健康未孕妇女血浆LPA水均正常，正常晚期妊娠孕妇血浆LPA水平明显大于临界值，妊娠期高血压孕妇血浆LPA更高（P＜0.05）。血浆LPA水平随妊娠期高血压病情程度不断升高（P＜0.05）。结论妊娠期高血压患者LPA水平明显升高，随病情程度进展不断升高，LPA可能参与了妊娠期高血压的发生和发展过程，能够作为妊娠期高血压的诊断和预后评估的重要临床指标。
목적：관찰L PA수평표체，병대기림상의의진행분석。방법입선근년래취진우려만구제이인민의원적임신기고혈압환자90례작위관찰A조，동기선취30례정상만기임신부녀위관찰B조，미잉건강부녀30례위대조조，분별검측LPA수평，탐토LPA화임신기고혈압적관계；임신기고혈압잉부근거병정정도분위임신기고혈압조、경도자간전기조화중도자간전기조，비교3조LPA수평。결과건강미잉부녀혈장LPA수균정상，정상만기임신잉부혈장LPA수평명현대우림계치，임신기고혈압잉부혈장LPA경고（P＜0.05）。혈장LPA수평수임신기고혈압병정정도불단승고（P＜0.05）。결론임신기고혈압환자LPA수평명현승고，수병정정도진전불단승고，LPA가능삼여료임신기고혈압적발생화발전과정，능구작위임신기고혈압적진단화예후평고적중요림상지표。
Objective To observe the expression levels of LPA and its effect on clinical significance. Methods 90 preg‐nant patients with hypertension were chosen as observation group A ,and 30 healthy cases of late‐pregnant women in the same period as observation group B ,and 30 healthy non‐pregnant women as control group. LPA levels of the three groups were de‐tected respectively ,and relationship between LPA levels and pregnancy complication with hypertension was analyzed and dis‐cussed;Meanwhile ,the patients in observation group A were divided into gestational hypertension group ,mild preeclampsia group and severe preeclampsia group.Results Serum LPA levels of healthy women without pregnancy showed normal results , serum LPA levels in observation group B were high compared with threshold ,and serum LPA levels cases in observation group A hold obviously higher levels(P<0.05);and the severer condition of gestational hypertension was ,the higher the LPA levels (P<0.05). Conclusion LPA levels in patients with gestational hypertension increase with the severity of disease. LPA may be involved in onset and development of gestational hypertension ,which can be regarded as an important indicator for evaluation of diagnosis and prognosis of gestational hypertension.