CAJ | 학술논문

[目的]观察自拟益气养阴消癌方治疗老年晚期气阴两虚型非小细胞肺癌（NSCLC）患者的临床疗效。[方法]将60例符合入选标准的肺癌患者，随机分为自拟方组和参麦组各30例，两组在采用共同化疗方案的基础上，自拟方组联合使用自拟益气养阴消癌方治疗，参麦组联合使用参麦注射液治疗。治疗6周后，观察评价两组患者中医症候积分和生存质量，并行统计学分析。[结果]①治疗后自拟方组中医症状积分较治疗前明显改善（P<0．01），且优于参麦组（P<0．05）。②治疗后自拟方组生存质量高于参麦组（P＜0．05），能够更好达到减毒增效的正向作用。[结论]对化疗期间老年晚期气阴两虚型非小细胞肺癌患者，自拟益气养阴消癌方联合化疗能够增强化疗的近期疗效，减少部分毒副反应，提高生存率、生存质量，改善体能状态，起到增效减毒的作用，值得今后增大样本量和合理延长试验时间进一步研究。
[목적]관찰자의익기양음소암방치료노년만기기음량허형비소세포폐암（NSCLC）환자적림상료효。[방법]장60례부합입선표준적폐암환자，수궤분위자의방조화삼맥조각30례，량조재채용공동화료방안적기출상，자의방조연합사용자의익기양음소암방치료，삼맥조연합사용삼맥주사액치료。치료6주후，관찰평개량조환자중의증후적분화생존질량，병행통계학분석。[결과]①치료후자의방조중의증상적분교치료전명현개선（P<0．01），차우우삼맥조（P<0．05）。②치료후자의방조생존질량고우삼맥조（P＜0．05），능구경호체도감독증효적정향작용。[결론]대화료기간노년만기기음량허형비소세포폐암환자，자의익기양음소암방연합화료능구증강화료적근기료효，감소부분독부반응，제고생존솔、생존질량，개선체능상태，기도증효감독적작용，치득금후증대양본량화합리연장시험시간진일보연구。
Objective]To observe the efficacy of the formulation of nourishing Qi and yin and anticancer on advanced non-small cell lung cancer(NSCLC) of Qi and yin deficiency of the elderly. [Method]60 patients were randomly divided into 2 groups: group of formulation of nourishing Qi and yin and anticancer in combination with chemotherapy(formulation group) and group of shenmai injection in combination with chemotherapy(shenmai group) ,each group included 30 cases.On the basis of using common chemotherapy regimens,the formulation group used formulation of nourishing Qi and yin and anticancer to treat,and shenmai group used shenmai injection to treat.After 6 weeks' treatment,observe the TCM symptom integral evaluation score and patients' quality of life of the two groups,and do statistical analysis.[Results] (1) After treatment,TCM symptom integral evaluation score of the formulation group was more significantly improved than before treatment(P<0.01),and was superior to the shenmai group(P<0.05).(2)After treatment,quality of life of the formulation group was more significantly improved than shenmai group( P<0.05). Therefore,the formulation group can achieve positive effect of attenuated synergies.[Conclusion]To the Qi and Yin deficiency type of advanced non-small cell lung cancer patients ,formulation of nourishing Qi and yin and anticancer can improve the early anticancer effect of chemotherapy,reduce some adverse reaction,improve the survival rates and quality of life, improve physical condition,having the effect of increasing effect and reducing toxicity.And its efficacy is better than shenmai injection, worth increasing sample sizes and reasonable extension of the test time for further study .