CAJ | 학술논문

缺血性脑卒中是全世界疾病中致残或致死的主要原因。研究发现基质金属蛋白酶－2（ MMP－2）与基质金属蛋白酶－9（MMP－9）在缺血性脑损伤中发挥了重要的作用，其参与了血脑屏障的破坏、脑水肿及出血性转化等过程，因此抑制MMP－2、MMP－9成为治疗的关键。针刺早期介入治疗能够有效地抑制MMP－2、MMP－9，且具有安全、操作简便、经济等优点，是治疗脑缺血损伤的一种新途径。故本研究将MMP－2、MMP－9与脑缺血的关系以及针刺的治疗作用做以综述。
결혈성뇌졸중시전세계질병중치잔혹치사적주요원인。연구발현기질금속단백매－2（ MMP－2）여기질금속단백매－9（MMP－9）재결혈성뇌손상중발휘료중요적작용，기삼여료혈뇌병장적파배、뇌수종급출혈성전화등과정，인차억제MMP－2、MMP－9성위치료적관건。침자조기개입치료능구유효지억제MMP－2、MMP－9，차구유안전、조작간편、경제등우점，시치료뇌결혈손상적일충신도경。고본연구장MMP－2、MMP－9여뇌결혈적관계이급침자적치료작용주이종술。
Ischemic stroke is the leading cause of disability or death all over the world.The study finds that matrix metalloproteinase-2 ( MMP-2 ) and matrix metalloproteinase-9 ( MMP-9 ) play important roles in is-chemic brain injury.They involve in the destruction of the blood brain barrier, brain edema and hemorrhagic transformation process.Therefore, it is the key to inhibiting the activities of MMP-2 and MMP-9.The early intervention of acupuncture can inhibit the activities of MMP-2 and MMP-9 effectively, and it is safe and easy to operate.It is also economical.It may be a new way for the treatment of cerebral ischemia injury.The relationship between MMP-2 and MMP-9 and cerebral ischemia and the therapeutic effect of acupuncture are reviewed as follows.