实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
5期
56-58
,共3页
心肌炎%丙种球蛋白%心肌损伤指标%治疗结果
心肌炎%丙種毬蛋白%心肌損傷指標%治療結果
심기염%병충구단백%심기손상지표%치료결과
Myocarditis%Gamma globulin%Myocardial injury markers%Treatment outcome
目的：探讨丙种球蛋白治疗重症心肌炎的临床疗效及对心肌损伤指标的影响。方法选取2010年5月—2013年5月汕头市潮阳区大峰医院收治的70例重症心肌炎患者，随机分为对照组和观察组，每组35例。对照组患者采用综合治疗（维生素、地塞米松、阿昔洛韦），观察组患者在对照组基础上加用丙种球蛋白治疗。比较两组患者临床疗效，治疗前及治疗2周、1个月、3个月后心功能指标〔左心室内径（ LV）、左心室射血分数（ LVEF）〕，治疗前及治疗1个月后心肌损伤指标〔心肌肌钙蛋白（ cTnT）、肌酸激酶同工酶（ CK-MB）、B型脑钠肽（ BNP）水平〕。结果观察组患者痊愈18例、好转15例、无效2例，对照组患者痊愈10例、好转19例、无效6例，观察组患者临床疗效优于对照组（u=1.950，P=0.025）；治疗前及治疗2周后两组患者LV、LVEF比较，差异无统计学意义（P>0.05）；治疗1个月、3个月后观察组患者LV小于对照组，LVEF高于对照组（P<0.05）。治疗前两组患者血清cTnT、CK-MB、BNP水平比较，差异无统计学意义（ P>0.05）；治疗1个月后观察组患者血清cTnT、CK-MB、BNP水平均低于对照组（P<0.05）。结论丙种球蛋白治疗重症心肌炎的临床疗效确切，且能有效改善心肌损伤指标。
目的：探討丙種毬蛋白治療重癥心肌炎的臨床療效及對心肌損傷指標的影響。方法選取2010年5月—2013年5月汕頭市潮暘區大峰醫院收治的70例重癥心肌炎患者，隨機分為對照組和觀察組，每組35例。對照組患者採用綜閤治療（維生素、地塞米鬆、阿昔洛韋），觀察組患者在對照組基礎上加用丙種毬蛋白治療。比較兩組患者臨床療效，治療前及治療2週、1箇月、3箇月後心功能指標〔左心室內徑（ LV）、左心室射血分數（ LVEF）〕，治療前及治療1箇月後心肌損傷指標〔心肌肌鈣蛋白（ cTnT）、肌痠激酶同工酶（ CK-MB）、B型腦鈉肽（ BNP）水平〕。結果觀察組患者痊愈18例、好轉15例、無效2例，對照組患者痊愈10例、好轉19例、無效6例，觀察組患者臨床療效優于對照組（u=1.950，P=0.025）；治療前及治療2週後兩組患者LV、LVEF比較，差異無統計學意義（P>0.05）；治療1箇月、3箇月後觀察組患者LV小于對照組，LVEF高于對照組（P<0.05）。治療前兩組患者血清cTnT、CK-MB、BNP水平比較，差異無統計學意義（ P>0.05）；治療1箇月後觀察組患者血清cTnT、CK-MB、BNP水平均低于對照組（P<0.05）。結論丙種毬蛋白治療重癥心肌炎的臨床療效確切，且能有效改善心肌損傷指標。
목적：탐토병충구단백치료중증심기염적림상료효급대심기손상지표적영향。방법선취2010년5월—2013년5월산두시조양구대봉의원수치적70례중증심기염환자，수궤분위대조조화관찰조，매조35례。대조조환자채용종합치료（유생소、지새미송、아석락위），관찰조환자재대조조기출상가용병충구단백치료。비교량조환자림상료효，치료전급치료2주、1개월、3개월후심공능지표〔좌심실내경（ LV）、좌심실사혈분수（ LVEF）〕，치료전급치료1개월후심기손상지표〔심기기개단백（ cTnT）、기산격매동공매（ CK-MB）、B형뇌납태（ BNP）수평〕。결과관찰조환자전유18례、호전15례、무효2례，대조조환자전유10례、호전19례、무효6례，관찰조환자림상료효우우대조조（u=1.950，P=0.025）；치료전급치료2주후량조환자LV、LVEF비교，차이무통계학의의（P>0.05）；치료1개월、3개월후관찰조환자LV소우대조조，LVEF고우대조조（P<0.05）。치료전량조환자혈청cTnT、CK-MB、BNP수평비교，차이무통계학의의（ P>0.05）；치료1개월후관찰조환자혈청cTnT、CK-MB、BNP수평균저우대조조（P<0.05）。결론병충구단백치료중증심기염적림상료효학절，차능유효개선심기손상지표。
Objective To investigate the clinical effect of gamma globulin on severe myocarditis and its impact on myocardial damage markers. Methods From May 2010 May 2013,a total of 70 patients with severe myocarditis were selected in Dafeng Hospital of Shantou, and they were randomly divided into control group and observation group, each of 35 cases. Patients of control group were given comprehensive treatment,including vitamins,dexamethasone,acyclovir and so on, while patients of observation group were given gamma globulin based on comprehensive treatment. Clinical effect,cardiac function index(including LV and LVEF) before treatment and after 2 weeks,1 month,3 months of treatment,myocardial damage markers(including serum levels of cTNT,CK -MB,BNP) before treatment and after 1 month of treatment were compared between the two groups. Results In observation group,18 cases were cured,15 cases got better,2 cases were invalid;in control group,10 cases were cured,19 cases got better,6 cases were invalid. The clinical effect of observation group was statistically significantly better than that of control group(u=1. 950,P=0. 025). No statistically significant differences of LV or LVEF was found between the two groups before treatment or after 2 weeks of treatment(P>0. 05);while after 1 month and 3 months of treatment,LV of observation group was statistically significantly shorter than that of control group,LVEF of observation group was statistically significantly higher than that of control group(P<0. 05). No statistically significant differences of serum levels of cTNT,CK - MB,BNP was found between the two groups before treatment(P >0. 05);while after 1 month of treatment,serum levels of cTNT,CK-MB,BNP of observation group were statistically significantly lower than those of control group(P<0. 05). Conclusion Gamma globulin has certain clinical effect in treating severe myocarditis,and can effectively improve the myocardial damage markers.
