临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2015年
3期
57-59
,共3页
原发性高血压%心身疾病%焦虑症状%坦度螺酮%缬沙坦%降压治疗%生活质量%汉密顿焦虑量表%中国心血管病人生活质量评定问卷%副反应量表
原髮性高血壓%心身疾病%焦慮癥狀%坦度螺酮%纈沙坦%降壓治療%生活質量%漢密頓焦慮量錶%中國心血管病人生活質量評定問捲%副反應量錶
원발성고혈압%심신질병%초필증상%탄도라동%힐사탄%강압치료%생활질량%한밀돈초필량표%중국심혈관병인생활질량평정문권%부반응량표
Essential hypertension%psychosomatic disease%anxious symptom%tandospirone%valsartan%depressurization treatment%quality of life%HAMA%CCQQ%TESS
目的：探讨坦度螺酮治疗原发性高血压伴焦虑症状患者的临床疗效和安全性。方法将60例原发性高血压伴焦虑症状患者按入组顺序分为两组，均口服缬沙坦常规降压治疗，研究组在此基础上口服坦度螺酮治疗，观察8周。治疗前后监测血压变化，采用汉密顿焦虑量表评定焦虑状况，中国心血管病人生活质量评定问卷评定生活质量，副反应量表评定不良反应。结果治疗8周末研究组汉密顿焦虑量表总分较治疗前显著下降，中国心血管病人生活质量评定问卷各维度评分较治疗前显著升高（P＜0．01），对照组治疗前后评分均无显著变化（P＞0．05）；研究组降压总有效率为73．3％，对照组为46．7％，研究组显著高于对照组（χ2＝4．44，P＜0．05）。研究组出现倦怠、口干、便秘、胃肠道不适发生率高于对照组，但两组副反应量表评分比较差异无显著性（P＞0．05）。结论对原发性高血压伴焦虑症状患者在常规应用降压药物的基础上联合坦度螺酮治疗，能显著改善患者的焦虑症状、提高降压疗效和生活质量，安全性高，优于单用降压药物治疗。
目的：探討坦度螺酮治療原髮性高血壓伴焦慮癥狀患者的臨床療效和安全性。方法將60例原髮性高血壓伴焦慮癥狀患者按入組順序分為兩組，均口服纈沙坦常規降壓治療，研究組在此基礎上口服坦度螺酮治療，觀察8週。治療前後鑑測血壓變化，採用漢密頓焦慮量錶評定焦慮狀況，中國心血管病人生活質量評定問捲評定生活質量，副反應量錶評定不良反應。結果治療8週末研究組漢密頓焦慮量錶總分較治療前顯著下降，中國心血管病人生活質量評定問捲各維度評分較治療前顯著升高（P＜0．01），對照組治療前後評分均無顯著變化（P＞0．05）；研究組降壓總有效率為73．3％，對照組為46．7％，研究組顯著高于對照組（χ2＝4．44，P＜0．05）。研究組齣現倦怠、口榦、便祕、胃腸道不適髮生率高于對照組，但兩組副反應量錶評分比較差異無顯著性（P＞0．05）。結論對原髮性高血壓伴焦慮癥狀患者在常規應用降壓藥物的基礎上聯閤坦度螺酮治療，能顯著改善患者的焦慮癥狀、提高降壓療效和生活質量，安全性高，優于單用降壓藥物治療。
목적：탐토탄도라동치료원발성고혈압반초필증상환자적림상료효화안전성。방법장60례원발성고혈압반초필증상환자안입조순서분위량조，균구복힐사탄상규강압치료，연구조재차기출상구복탄도라동치료，관찰8주。치료전후감측혈압변화，채용한밀돈초필량표평정초필상황，중국심혈관병인생활질량평정문권평정생활질량，부반응량표평정불량반응。결과치료8주말연구조한밀돈초필량표총분교치료전현저하강，중국심혈관병인생활질량평정문권각유도평분교치료전현저승고（P＜0．01），대조조치료전후평분균무현저변화（P＞0．05）；연구조강압총유효솔위73．3％，대조조위46．7％，연구조현저고우대조조（χ2＝4．44，P＜0．05）。연구조출현권태、구간、편비、위장도불괄발생솔고우대조조，단량조부반응량표평분비교차이무현저성（P＞0．05）。결론대원발성고혈압반초필증상환자재상규응용강압약물적기출상연합탄도라동치료，능현저개선환자적초필증상、제고강압료효화생활질량，안전성고，우우단용강압약물치료。
Objective To explore the efficacy and safety of tandospirone in essential hypertension patient with anxious symptoms .Methods Sixty essential hypertension patient with anxious symptoms were as‐signed to two groups according to enrollment order ,both gropups took orally valsartan ,on this basis re‐search group was plus oral tandospirone for 8 weeks .Before and after treatment blood pressure (BP) chan‐ges were monitored ,anxiety conditions assessed with the Hamilton Anxiety Scale (HAMA) ,qualities of life with China Cardiovascular Quality of Life Questionnaire (CCQQ ) ,and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 8th week the HAMA total score lowered more significantly and each dimension score of the CCQQ heightened (P<0 .01) compared with pretreatment in research group ,those had no significant changes in control group (P>0 .05);total effec‐tive rate of depressurization was respectively 73 .3% in research and 46 .7% in control group ,the former was significantly higher than the latter (χ2 = 4 .44 ,P< 0 .05) .The incidences of tiredness ,dry mouth , constipation and gastrointestinal indisposition were higher in research than in control group ,there was no significant group difference in the TESS scores (P>0 .05) .Conclusion Routine antihypertensive drug plus tandospirone could notably improve anxious symptoms ,depressurization efficacy and quality of life and has higher safety compared with single antihypertensive drug in essential hypertension patient with anxious symptoms .
