临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2015年
3期
51-53
,共3页
老年抑郁症%米氮平%帕罗西汀%汉密顿抑郁量表%副反应量表
老年抑鬱癥%米氮平%帕囉西汀%漢密頓抑鬱量錶%副反應量錶
노년억욱증%미담평%파라서정%한밀돈억욱량표%부반응량표
Senile depression%mirtazapine%paroxetine%HAMD%TESS
目的:探讨米氮平与帕罗西汀治疗老年抑郁症的临床疗效和安全性。方法将80例抑郁症患者随机分为米氮平组和帕罗西汀组,每组40例,分别口服米氮平和帕罗西汀治疗,观察6周。于治疗前后采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应。结果治疗后两组汉密顿抑郁量表评分均较治疗前有显著下降(P<0.01),同期两组评分比较差异无显著性( P>0.05);治疗6周末,米氮平组显效率92.5%,总有效率97.5%;帕罗西汀组分别为90.0%、97.5%,两组显效率、总有效率差异无显著性( P>0.05)。两组不良反应均轻微,米氮平组嗜睡、食欲增加、体质量增加发生率显著高于帕罗西汀组,合并苯二氮艹卓类药物应用率显著低于帕罗西汀组( P<0.05或0.01)。结论米氮平与帕罗西汀治疗老年抑郁症疗效显著,安全性高,依从性好,可作为治疗老年抑郁症的首选药物在临床推广应用。
目的:探討米氮平與帕囉西汀治療老年抑鬱癥的臨床療效和安全性。方法將80例抑鬱癥患者隨機分為米氮平組和帕囉西汀組,每組40例,分彆口服米氮平和帕囉西汀治療,觀察6週。于治療前後採用漢密頓抑鬱量錶評定臨床療效,副反應量錶評定不良反應。結果治療後兩組漢密頓抑鬱量錶評分均較治療前有顯著下降(P<0.01),同期兩組評分比較差異無顯著性( P>0.05);治療6週末,米氮平組顯效率92.5%,總有效率97.5%;帕囉西汀組分彆為90.0%、97.5%,兩組顯效率、總有效率差異無顯著性( P>0.05)。兩組不良反應均輕微,米氮平組嗜睡、食欲增加、體質量增加髮生率顯著高于帕囉西汀組,閤併苯二氮艸卓類藥物應用率顯著低于帕囉西汀組( P<0.05或0.01)。結論米氮平與帕囉西汀治療老年抑鬱癥療效顯著,安全性高,依從性好,可作為治療老年抑鬱癥的首選藥物在臨床推廣應用。
목적:탐토미담평여파라서정치료노년억욱증적림상료효화안전성。방법장80례억욱증환자수궤분위미담평조화파라서정조,매조40례,분별구복미담평화파라서정치료,관찰6주。우치료전후채용한밀돈억욱량표평정림상료효,부반응량표평정불량반응。결과치료후량조한밀돈억욱량표평분균교치료전유현저하강(P<0.01),동기량조평분비교차이무현저성( P>0.05);치료6주말,미담평조현효솔92.5%,총유효솔97.5%;파라서정조분별위90.0%、97.5%,량조현효솔、총유효솔차이무현저성( P>0.05)。량조불량반응균경미,미담평조기수、식욕증가、체질량증가발생솔현저고우파라서정조,합병분이담초탁류약물응용솔현저저우파라서정조( P<0.05혹0.01)。결론미담평여파라서정치료노년억욱증료효현저,안전성고,의종성호,가작위치료노년억욱증적수선약물재림상추엄응용。
Objective To explore the efficacy and safety of mirtazapine and paroxetine in the treatment of senile depression .Methods Eighty depression patients were randomly assigned to two groups of 40 ones each and took orally mirtazapine or paroxetine for 6 weeks .Efficacies were assessed with the Hamilton De‐pression Scale (HAMD) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results After treatment the HAMD scores of both groups lowered more signifi‐cantly compared with pretreatment (P< 0 .01) ,there was no significant group difference in the corre‐sponding period (P>0 .05);At the end of the 6th week obvious and total effective rate were respectively 92 .5% and 97 .5% in mirtazapine and 90 .0% and 97 .5% in paroxetine group ,which showed no significant differences (P>0 .05) .Adverse reactions of both groups were mild ,the incidences of hypersomnia ,hy‐perorexia and weight gain were significantly higher and use rate of combination with benzodiazepines lower in mirtazapine than in paroxetine group (P<0 .05 or 0 .01) .Conclusion Both mirtazapine and paroxetine are effective ,have higher safety and better compliance ,and could serve as choice drugs for senile depres‐sio n .