CAJ | 학술논문

目的：探讨草酸艾司西酞普兰联合健脑宁口服液治疗抑郁症的临床疗效和安全性。方法将100例抑郁症患者随机分为两组，每组50例，均口服草酸艾司西酞普兰治疗，研究组联合健脑宁口服液治疗，观察4周。于治疗前后采用汉密顿焦虑量表、汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗4周末两组汉密顿焦虑量表、汉密顿抑郁量表总分均较治疗前显著性下降（P＜0．01），研究组较对照组下降更显著（P＜0．05或0．01）；研究组有效率为98．0％，对照组为88．0％，研究组有效率显著高于对照组（ P＜0．05）。两组不良反应主要表现为口干、兴奋、头昏、便秘等，发生率比较差异无显著性（χ2＝2．64，P＞0．05）。结论草酸艾司西酞普兰联合健脑宁口服液治疗抑郁症具有增效作用，且不增加不良反应，安全性高，优于单用艾司西酞普兰治疗。
목적：탐토초산애사서태보란연합건뇌저구복액치료억욱증적림상료효화안전성。방법장100례억욱증환자수궤분위량조，매조50례，균구복초산애사서태보란치료，연구조연합건뇌저구복액치료，관찰4주。우치료전후채용한밀돈초필량표、한밀돈억욱량표평정림상료효，부반응량표평정불량반응。결과치료4주말량조한밀돈초필량표、한밀돈억욱량표총분균교치료전현저성하강（P＜0．01），연구조교대조조하강경현저（P＜0．05혹0．01）；연구조유효솔위98．0％，대조조위88．0％，연구조유효솔현저고우대조조（ P＜0．05）。량조불량반응주요표현위구간、흥강、두혼、편비등，발생솔비교차이무현저성（χ2＝2．64，P＞0．05）。결론초산애사서태보란연합건뇌저구복액치료억욱증구유증효작용，차불증가불량반응，안전성고，우우단용애사서태보란치료。
Objective To explore the efficacy and safety of escitalopram oxalate combined with jiannaoning oral liquid in the treatment of depression .Methods A total of 100 depression patients were randomly di‐vided into two groups of 50 ones each ,both groups took orally escitalopram oxalate ,and research group was plus jiannaoning oral liquid for 4 weeks .Efficacies were assessed with the Hamilton Anxiety Scale (HAMA)and Hamilton Depression Scale(HAMD)before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 4th week the HAMA and HDMD total scores of both groups lowered more significantly compared with pretreatment (P<0 .01) ,so did those in research than in control group (P<0 .05 or 0 .01);Effective rate was significantly higher in research than in control group (98 .0% vs .88 .0% , P<0 .05) .Adverse reactions of both groups were mainly dry mouth ,excitation ,dizziness ,constipation and so on ,their incidences had no significant group differences (χ2 =2 .64 ,P>0 .05) .Conclusion Escitalopram oxalate combined with jiannaoning oral liquid has a synergism ,doesn’t increase adverse reactions ,and has higher safety compared with single escitalo‐pram oxalate in the treatment of depression .