CAJ | 학술논문

目的：探讨氟西汀联合米氮平治疗难治性抑郁症的疗效和安全性。方法将73例难治性抑郁症患者随机分为两组，均口服氟西汀治疗，研究组联合米氮平治疗，观察8周。于治疗前后采用汉密顿抑郁量表、汉密顿焦虑量表评定临床疗效，副反应量表评定不良反应。结果治疗2周末起两组汉密顿抑郁量表、汉密顿焦虑量表评分均较治疗前显著下降（ P＜0．05或0．01），研究组治疗4周、8周末汉密顿抑郁量表、汉密顿焦虑量表评分较对照组下降更显著（P＜0．01），治疗8周末总有效率显著高于对照组（P＜0．05）。两组不良反应程度均为轻度到中度，发生率比较差异无显著性（P＞0．05）。结论氟西汀联合米氮平治疗难治性抑郁症疗效优于单用氟西汀，且不增加不良反应。
목적：탐토불서정연합미담평치료난치성억욱증적료효화안전성。방법장73례난치성억욱증환자수궤분위량조，균구복불서정치료，연구조연합미담평치료，관찰8주。우치료전후채용한밀돈억욱량표、한밀돈초필량표평정림상료효，부반응량표평정불량반응。결과치료2주말기량조한밀돈억욱량표、한밀돈초필량표평분균교치료전현저하강（ P＜0．05혹0．01），연구조치료4주、8주말한밀돈억욱량표、한밀돈초필량표평분교대조조하강경현저（P＜0．01），치료8주말총유효솔현저고우대조조（P＜0．05）。량조불량반응정도균위경도도중도，발생솔비교차이무현저성（P＞0．05）。결론불서정연합미담평치료난치성억욱증료효우우단용불서정，차불증가불량반응。
Objective To Explore the efficacy and safety of fluoxetine combined with mirtazapine in the treatment of treatment‐resistant depression (TRD) .Methods Seventy‐three TRD patients were randomly assigned to two groups ,both groups took orally fluoxetine ,and research group was plus mirtazapine for 8 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) and adverse reactions with the Treatment Emergent Symptom scale(TESS) before and after treatment .Results Since the end of the 2nd week the HAMD and HAMA scores of both groups lowered more significantly compared with pretreatment (P<0 .05 or 0 .01) ,so did those at the end of the 4th and 8th week (P<0 .05 or 0 .01)and total effective rate at the end of the 8th week was significantly higher (P<0 .05) in research than in control group .Adverse reactions of both groups were mild to moderate ,their in‐cidences had no significant group difference (P>0 .05) .Conclusion Fluoxetine combined with mirtazapine is more effective and doesn’t increase adverse reactions compared with single fluoxetine in treatment‐resist‐ant depression .