CAJ | 학술논문

目的：探讨阿立哌唑与利培酮对首发精神分裂症患者临床疗效和认知功能的影响。方法将68例首发精神分裂症患者随机分为两组，研究组口服阿立哌唑治疗，对照组口服利培酮治疗，观察12周。于治疗前后采用阳性与阴性症状量表评定精神症状，蒙特利尔认知评价量表评定认知功能。结果治疗后两组阳性与阴性症状量表总分及各因子分均较治疗前显著下降（P＜0．05或0．01），研究组治疗第2周末阳性症状因子分显著高于对照组（P＜0．05），治疗第4周、8周、12周末阴性症状因子分显著低于对照组（ P＜0．05或0．01）。治疗12周末两组蒙特利尔认知评价量表总分及各因子分均较治疗前显著升高（ P＜0．05或0．01），研究组治疗第4周、8周、12周末总分及注意、延迟回忆因子分显著高于对照组（ P＜0．05或0．01）。结论阿立哌唑与利培酮均能有效控制精神分裂症患者的精神症状，改善认知功能，但利培酮对阳性症状控制起效快于阿立哌唑，阿立哌唑对阴性症状、认知功能的注意、回忆的改善优于利培酮。
목적：탐토아립고서여리배동대수발정신분렬증환자림상료효화인지공능적영향。방법장68례수발정신분렬증환자수궤분위량조，연구조구복아립고서치료，대조조구복리배동치료，관찰12주。우치료전후채용양성여음성증상량표평정정신증상，몽특리이인지평개량표평정인지공능。결과치료후량조양성여음성증상량표총분급각인자분균교치료전현저하강（P＜0．05혹0．01），연구조치료제2주말양성증상인자분현저고우대조조（P＜0．05），치료제4주、8주、12주말음성증상인자분현저저우대조조（ P＜0．05혹0．01）。치료12주말량조몽특리이인지평개량표총분급각인자분균교치료전현저승고（ P＜0．05혹0．01），연구조치료제4주、8주、12주말총분급주의、연지회억인자분현저고우대조조（ P＜0．05혹0．01）。결론아립고서여리배동균능유효공제정신분렬증환자적정신증상，개선인지공능，단리배동대양성증상공제기효쾌우아립고서，아립고서대음성증상、인지공능적주의、회억적개선우우리배동。
Objective To explore influences of aripiprazole and risperidone on efficacy and cognitive func‐tions of patients with first‐episode schizophrenia .Methods Sixty‐eight first‐episode schizophrenics were randomly assigned to two groups ,research group took orally aripiprazole and control group did risperidone for 12 weeks .Mental symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions with Montreal Cognitive Assessment (MoCA) before and after treatment .Results After treatment the total and each factor scores of the PANSS of both groups lowered more significantly compared with pretreatment (P<0 .05 or 0 .01) ,positive symptoms scores at the end of the 2nd week were significantly higher (P<0 .05) and negative symptoms at the end of the 4th ,8th and 12th lower (P<0 .05 or 0 .01) in research than in control group .At the end of the 12th week the total and each factor scores of the MoCA of both groups heightened more significantly compared with pretreatment (P<0 .05 or 0 .01) ,the total ,attention and delayed memory scores at the end of the 4th ,8th and 12th week were significantly higher in research than in control group (P<0 .05 or 0 .01) .Conclusion Both aripiprazole and risperidone colud effectively control schizophrenic mental symptoms and improve cognitive functions ,but risperidone takes effect more rapidly in controlling positive symptoms ,aripiprazole has an advantage over risperidone in the improvement of negative symptoms ,attention and memory .