CAJ | 학술논문

帕金森病是常见的老年神经变性疾病，目前机制不清，无有效的治疗方法。线粒体功能障碍与帕金森病密切相关。认为，某些常见的环境因素和身体状态，如环境毒物、受寒、人体的免疫反应、炎症因子、感染、应激状态等，可导致多巴胺能神经元等常见易损伤的细胞发生能量矛盾，并因此造成线粒体损伤累积，认为这是导致帕金森病发病和病情进展的主要推动力。针对能量矛盾的产生，采取减少能量干扰和促进线粒体功能的策略，将会对阻止帕金森病的进展和研发有效的治疗方法，起到良好的促进作用。
파금삼병시상견적노년신경변성질병，목전궤제불청，무유효적치료방법。선립체공능장애여파금삼병밀절상관。인위，모사상견적배경인소화신체상태，여배경독물、수한、인체적면역반응、염증인자、감염、응격상태등，가도치다파알능신경원등상견역손상적세포발생능량모순，병인차조성선립체손상루적，인위저시도치파금삼병발병화병정진전적주요추동력。침대능량모순적산생，채취감소능량간우화촉진선립체공능적책략，장회대조지파금삼병적진전화연발유효적치료방법，기도량호적촉진작용。
Parkinson Disease is a common neurodegenerative movement disorder in elderly people without complete understanding of it's mechanism and with no effective therapies .This disease is closely related with the dysfunction of mitochondria .Some common environmental factors and physical status of the patients ,such as toxic substances of some drugs and pesticides ,cold weather ,immune response ,inflammation and inflammatory factors ,stress ,could induce energy pressure in the fragile dopaminergic cells and cause injuries accumulated in mitochondria ,which could be the driving force of this disease .The strategies to prevent the occurrence of energy pressure and to improve the energy producing ability of mitochondria might be important in preventing the progress of this disease .