医学与哲学
醫學與哲學
의학여철학
MEDICINE AND PHILOSOPHY
2015年
12期
56-58,77
,共4页
韩雨轩%傅枭男%丁社教%朱聪%丁先锋
韓雨軒%傅梟男%丁社教%硃聰%丁先鋒
한우헌%부효남%정사교%주총%정선봉
肠道菌群%肿瘤%防治
腸道菌群%腫瘤%防治
장도균군%종류%방치
gut microbiota%tumor%prevention and treatment
人体肠道微生物菌群是一个极其复杂的微生态系统,经过长期的协同进化,肠道菌群与宿主间形成了密切的共生关系,保持肠道菌群平衡对人体健康至关重要。肿瘤是由机体中局部组织的细胞失控导致异常增生与分化而形成的。肿瘤会破坏正常组织与器官,尤其是恶性肿瘤。肠道菌群能够通过激活抗肿瘤细胞因子、调节肠道环境、维持基因组稳定等途径抑制肿瘤的发生与发展,完整的肠道菌群有利于抗癌药物药效的发挥,肠道细菌在肿瘤治疗领域的应用日渐广泛。
人體腸道微生物菌群是一箇極其複雜的微生態繫統,經過長期的協同進化,腸道菌群與宿主間形成瞭密切的共生關繫,保持腸道菌群平衡對人體健康至關重要。腫瘤是由機體中跼部組織的細胞失控導緻異常增生與分化而形成的。腫瘤會破壞正常組織與器官,尤其是噁性腫瘤。腸道菌群能夠通過激活抗腫瘤細胞因子、調節腸道環境、維持基因組穩定等途徑抑製腫瘤的髮生與髮展,完整的腸道菌群有利于抗癌藥物藥效的髮揮,腸道細菌在腫瘤治療領域的應用日漸廣汎。
인체장도미생물균군시일개겁기복잡적미생태계통,경과장기적협동진화,장도균군여숙주간형성료밀절적공생관계,보지장도균군평형대인체건강지관중요。종류시유궤체중국부조직적세포실공도치이상증생여분화이형성적。종류회파배정상조직여기관,우기시악성종류。장도균군능구통과격활항종류세포인자、조절장도배경、유지기인조은정등도경억제종류적발생여발전,완정적장도균군유리우항암약물약효적발휘,장도세균재종류치료영역적응용일점엄범。
The microbiota in the human gut is an extremely complex community ,after a long‐term coevolution .The bacteria and their hosts have a close symbiosis ,and to maintain a well‐balanced intestinal flora is vitally important to human health . A tumor , arises from abnormal grow th and differentiation of body cells , is harmful to normal tissues and organs . Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis ,compared to benign neoplasms . Gut microbiota can inhibit the occurrence and development of the tumor by activating anti‐tumor cytokines ,regulating the gut environment ,maintaining genomic stability and so on ,and they are able to improve the therapeutic efficacy of the anti‐tumor drugs and they have been increasingly used in the tumor treatment .