临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
6期
1175-1179
,共5页
张娟(综述)%莫朝晖(审校)
張娟(綜述)%莫朝暉(審校)
장연(종술)%막조휘(심교)
糖代谢%胰岛素抵抗%胰岛β细胞%线粒体
糖代謝%胰島素牴抗%胰島β細胞%線粒體
당대사%이도소저항%이도β세포%선립체
PINK1%glucose metabolism%insulin resistance%pancreatic beta cell%mitochondria
同源性磷酸酶张力蛋白诱导的激酶1[phosphatase and tensin homologue (PTEN)-induced putative kinase 1，PINK1]是与帕金森相关的一种蛋白激酶，同线粒体功能密切相关。有研究表明，PINK1可能与肥胖、2型糖尿病(type 2 diabetes mellitus，T2DM)有关，在调节胰岛β细胞功能中有一定作用，某些治疗T2DM药物也参与PINK1途径调节。本文就近年关于PINK1与糖代谢相关研究进行综述。
同源性燐痠酶張力蛋白誘導的激酶1[phosphatase and tensin homologue (PTEN)-induced putative kinase 1，PINK1]是與帕金森相關的一種蛋白激酶，同線粒體功能密切相關。有研究錶明，PINK1可能與肥胖、2型糖尿病(type 2 diabetes mellitus，T2DM)有關，在調節胰島β細胞功能中有一定作用，某些治療T2DM藥物也參與PINK1途徑調節。本文就近年關于PINK1與糖代謝相關研究進行綜述。
동원성린산매장력단백유도적격매1[phosphatase and tensin homologue (PTEN)-induced putative kinase 1，PINK1]시여파금삼상관적일충단백격매，동선립체공능밀절상관。유연구표명，PINK1가능여비반、2형당뇨병(type 2 diabetes mellitus，T2DM)유관，재조절이도β세포공능중유일정작용，모사치료T2DM약물야삼여PINK1도경조절。본문취근년관우PINK1여당대사상관연구진행종술。
PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a protein kinase associated with Parkinson’s and closely related with mitochondrial function. Studies have shown that PINK1 may be involved in obesity, type 2 diabetes. Recent studies demonstrate that PINK1 is necessary to maintain function of pancreatic beta cells. Some diabetic drugs are also involved in the regulation of PINK1. hTis article reviewed the study on the correlation between PINK1 and glucose metabolism in recent years.
