医学与哲学
醫學與哲學
의학여철학
MEDICINE AND PHILOSOPHY
2015年
12期
42-44
,共3页
直肠癌%肠系膜下动脉根部%淋巴结微小转移
直腸癌%腸繫膜下動脈根部%淋巴結微小轉移
직장암%장계막하동맥근부%림파결미소전이
rectal carcinoma%root of inferior mesenteric artery%lymph node micrometastasis
研究直肠癌肠系膜下动脉（IM A ）根部淋巴结微小转移在全直肠系膜切除加1级、2级和3级淋巴结（D3淋巴结）清扫术中的意义。将48例直肠癌D3淋巴结清扫患者的141枚IM A根部淋巴结，进行 H E染色和免疫组化染色研究。常规HE染色结果，8例（32／141）患者的IMA根部淋巴结为转移阳性。常规 HE染色阳性组与肿瘤位置和组织病理学有相关性，其差异有统计学意义（ P＜0．05）。免疫组化染色结果，13例（38／109）患者的IM A根部淋巴结为微小转移阳性。免疫组化阳性组与肿瘤位置、组织病理学及肿瘤浸润深度有相关性，其差异有统计学意义（P＜0．05）。免疫组化组IMA根部淋巴结转移率明显高于常规HE染色组（P＜0．001）。直肠癌IMA根部淋巴结微小转移发生率高，直肠癌转移初期IM A根部淋巴结有微小转移，清扫IM A根部淋巴结对直肠癌D3淋巴结清扫有效。
研究直腸癌腸繫膜下動脈（IM A ）根部淋巴結微小轉移在全直腸繫膜切除加1級、2級和3級淋巴結（D3淋巴結）清掃術中的意義。將48例直腸癌D3淋巴結清掃患者的141枚IM A根部淋巴結，進行 H E染色和免疫組化染色研究。常規HE染色結果，8例（32／141）患者的IMA根部淋巴結為轉移暘性。常規 HE染色暘性組與腫瘤位置和組織病理學有相關性，其差異有統計學意義（ P＜0．05）。免疫組化染色結果，13例（38／109）患者的IM A根部淋巴結為微小轉移暘性。免疫組化暘性組與腫瘤位置、組織病理學及腫瘤浸潤深度有相關性，其差異有統計學意義（P＜0．05）。免疫組化組IMA根部淋巴結轉移率明顯高于常規HE染色組（P＜0．001）。直腸癌IMA根部淋巴結微小轉移髮生率高，直腸癌轉移初期IM A根部淋巴結有微小轉移，清掃IM A根部淋巴結對直腸癌D3淋巴結清掃有效。
연구직장암장계막하동맥（IM A ）근부림파결미소전이재전직장계막절제가1급、2급화3급림파결（D3림파결）청소술중적의의。장48례직장암D3림파결청소환자적141매IM A근부림파결，진행 H E염색화면역조화염색연구。상규HE염색결과，8례（32／141）환자적IMA근부림파결위전이양성。상규 HE염색양성조여종류위치화조직병이학유상관성，기차이유통계학의의（ P＜0．05）。면역조화염색결과，13례（38／109）환자적IM A근부림파결위미소전이양성。면역조화양성조여종류위치、조직병이학급종류침윤심도유상관성，기차이유통계학의의（P＜0．05）。면역조화조IMA근부림파결전이솔명현고우상규HE염색조（P＜0．001）。직장암IMA근부림파결미소전이발생솔고，직장암전이초기IM A근부림파결유미소전이，청소IM A근부림파결대직장암D3림파결청소유효。
To investigate factors affecting the lymph node micrometastasis around the root of inferior mesenteric artery (IMA) in total mesorectum excision with D3 lymph node dissection .A total of 141 lymph nodes of the IMA root ,obtained from 48 patients with D3 lymph node dissection of rectal carcinoma were evaluated using HE staining and immunohistochemistry .Lymph node metastasis around the root of IMA was found in 32 of 141 nodes of 8 patients by routine HE staining . The HE staining positive group had a significantly low tumor location and poorly histological classification (P<0 .05) .Lymph node micrometastasis the root of IMA was immunohistochemically detected in 38 of 109 negative nodes from 13 of 40 patients .The immunohistochemistry positive group had a significantly low tumor location , poorly histological classification ,and higher deep of invasion (P<0 .05) .The lymph node metastasis rate of IMA root was higher by immunohistochemistry group than by HE staining group (P< 0 .001) .We have high rate of Lymph node metastasis around the root of IMA with rectal carcinoma ,and have confirmed that IMA root of D3 lymph node dissection is effective for radical surgery patients . Lymph node micrometastasis around the root of IM A is observed in the early metastasis stage of rectal carcinoma .
