CAJ | 학술논문

目的：评估大剂量羟考酮缓释片治疗晚期癌痛患者的疗效及安全性。方法回顾性分析大剂量或超大剂量羟考酮缓释片镇痛治疗20例晚期癌痛患者的疗效及毒副作用等。结果80％（16／20）患者的癌症疼痛得到了较好的控制，平均 NRS 疼痛评分从7．32降至2．68（P ＜0．05），羟考酮缓释片平均剂量从187．89 mg 增至276．84 mg（P ＜0．05），生活质量改善（P ＜0．05）。消化道反应、便秘等是常见的不良反应，未出现Ⅲ度及以上不良反应，安全性较好。结论晚期癌痛患者采取大剂量羟考酮缓释片疗效较确切，不良反应可以耐受。
목적：평고대제량간고동완석편치료만기암통환자적료효급안전성。방법회고성분석대제량혹초대제량간고동완석편진통치료20례만기암통환자적료효급독부작용등。결과80％（16／20）환자적암증동통득도료교호적공제，평균 NRS 동통평분종7．32강지2．68（P ＜0．05），간고동완석편평균제량종187．89 mg 증지276．84 mg（P ＜0．05），생활질량개선（P ＜0．05）。소화도반응、편비등시상견적불량반응，미출현Ⅲ도급이상불량반응，안전성교호。결론만기암통환자채취대제량간고동완석편료효교학절，불량반응가이내수。
Objective To evaluate efficacy and safety of high -dose controlled-released(CR)oxycodone for cancer pain. Methods The efficacy and adverse reactions of advanced cancer patients treated with high -dose CR oxycodone was retrospective -ly analyzed.Results Cancer pain of 80%(16 /20) of patients treated with high-dose CR oxycodone were controlled .Mean nu-meric rating scale(NRS)decreased form 7.32 to 2.68(P <0.05).Mean dosage of CR oxycodone increased from 187.89mg to 276.84mg(P <0.05).Quality of life improved(P <0.05).The mainly side effects were constipation ,nausea,vomiting and so on,and no adverse reactions were over stage Ⅲ.It had good safety.Conclusion High-dose CR oxycodone for cancer pain is ef -fective,safe and tolerable.