实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
6期
889-891
,共3页
三维适形放射治疗%替莫唑胺%脑胶质瘤
三維適形放射治療%替莫唑胺%腦膠質瘤
삼유괄형방사치료%체막서알%뇌효질류
3-dimensional conformal radiotherapy%Temozolomide%Brain glioma
目的：探讨三维适形放射治疗联合替莫唑胺（TMZ）在脑胶质瘤治疗中的疗效及安全性。方法48例脑胶质细胞瘤术后患者随机分为观察组和对照组，观察组进行三维适形放疗联合 TMZ 治疗，而对照组只进行三维适形放疗。对2组的疗效、生存率和不良反应进行比较。结果观察组近期疗效有效率为54．2％，高于对照组33．3％，但差异无统计学意义，P ＞0．05。观察组1年生存率为87．5％，显著高于对照组45．8％；2年生存率为58．3％，显著高于对照组25．0％。2组1、2年生存率比较，差异均有统计学意义，P ＜0．05。2组患者的不良反应发生率相比较，差异无统计学意义，P ＞0．05。结论三维适形放射治疗联合 TMZ 治疗术后脑胶质瘤患者安全、有效，疗效优于单纯放疗，值得临床进一步推广。
目的：探討三維適形放射治療聯閤替莫唑胺（TMZ）在腦膠質瘤治療中的療效及安全性。方法48例腦膠質細胞瘤術後患者隨機分為觀察組和對照組，觀察組進行三維適形放療聯閤 TMZ 治療，而對照組隻進行三維適形放療。對2組的療效、生存率和不良反應進行比較。結果觀察組近期療效有效率為54．2％，高于對照組33．3％，但差異無統計學意義，P ＞0．05。觀察組1年生存率為87．5％，顯著高于對照組45．8％；2年生存率為58．3％，顯著高于對照組25．0％。2組1、2年生存率比較，差異均有統計學意義，P ＜0．05。2組患者的不良反應髮生率相比較，差異無統計學意義，P ＞0．05。結論三維適形放射治療聯閤 TMZ 治療術後腦膠質瘤患者安全、有效，療效優于單純放療，值得臨床進一步推廣。
목적：탐토삼유괄형방사치료연합체막서알（TMZ）재뇌효질류치료중적료효급안전성。방법48례뇌효질세포류술후환자수궤분위관찰조화대조조，관찰조진행삼유괄형방료연합 TMZ 치료，이대조조지진행삼유괄형방료。대2조적료효、생존솔화불량반응진행비교。결과관찰조근기료효유효솔위54．2％，고우대조조33．3％，단차이무통계학의의，P ＞0．05。관찰조1년생존솔위87．5％，현저고우대조조45．8％；2년생존솔위58．3％，현저고우대조조25．0％。2조1、2년생존솔비교，차이균유통계학의의，P ＜0．05。2조환자적불량반응발생솔상비교，차이무통계학의의，P ＞0．05。결론삼유괄형방사치료연합 TMZ 치료술후뇌효질류환자안전、유효，료효우우단순방료，치득림상진일보추엄。
Objective To explore the efficacy and safety of 3-dimensional conformal radiotherapy combined with temozo -lomide(TMZ) for brain glioma.Methods 48 patients with malignant brain glioma were randomly and averagely divided into theobservation group and the control group.The observation group were treated with 3-dimensional conformal radiotherapy combinedwith TMZ,and the control group received 3-dimensional conformal radiotherapy alone .The efficacy,survival rates and incidence ofadverse reactions of the 2 groups were observed and compared.Results The short-term curative effect of the observation groupwas 54.2%,which was higher than that of the control group 33.3%,but there was no significant difference between two groups(P >0.05).The 1-year survival rate of the observation group was 87.5%,which was significantly higher than that of the controlgroup 45.8%.The 2-year survival rate of the observation group was 58.3%,which was significantly higher than that of the controlgroup 25.0%.The difference between the 2 groups was statistically significant (P <0.05).The rate of adverse events betweenthe 2 groups had no significant difference (P >0.05).Conclusion 3-dimensional conformal radiotherapy combined with TMZfor brain glioma is safe and effective,and the curative effect is better than radiotherapy alone ,it is worthy of further promotion inclinical.
