实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
6期
853-855
,共3页
结肠癌%根治术%化疗%老年患者%预后%TNM 分期
結腸癌%根治術%化療%老年患者%預後%TNM 分期
결장암%근치술%화료%노년환자%예후%TNM 분기
Colon cancer%Radical resection%Chemotherapy%Elderly patients%Prognosis%TNM staging
目的：探讨结肠癌根治术辅助化疗对老年Ⅱ～Ⅲ期结肠癌患者的预后影响。方法将78例结肠癌患者按照是否化疗分为观察组38例和对照组40例。对照组患者只进行根治术，观察组患者在根治术后进行辅助化疗。观察2组患者的生命质量评价以及1年生存率、3年生存率和复发转移率。结果对照组患者的 GLQI 总分、生理功能状态及症状与体征评分均显著低于治疗前，且对照组患者治疗后的 GLQI 总分、生理功能状态及症状与体征评分也明显低于观察组患者，差异均具有统计学意义（P ＜0．05）。2组患者的1年生存率比较无明显差别（P ＞0．05），但是观察组患者的3年生存率明显高于对照组患者，且观察组患者的复发转移率显著低于对照组患者，差异均具有统计学意义（P ＜0．05）。结论在腹腔镜根治术后辅助化疗治疗，能提高患者的3年生存率，改善患者生命质量，并且能降低复发转移的风险。
目的：探討結腸癌根治術輔助化療對老年Ⅱ～Ⅲ期結腸癌患者的預後影響。方法將78例結腸癌患者按照是否化療分為觀察組38例和對照組40例。對照組患者隻進行根治術，觀察組患者在根治術後進行輔助化療。觀察2組患者的生命質量評價以及1年生存率、3年生存率和複髮轉移率。結果對照組患者的 GLQI 總分、生理功能狀態及癥狀與體徵評分均顯著低于治療前，且對照組患者治療後的 GLQI 總分、生理功能狀態及癥狀與體徵評分也明顯低于觀察組患者，差異均具有統計學意義（P ＜0．05）。2組患者的1年生存率比較無明顯差彆（P ＞0．05），但是觀察組患者的3年生存率明顯高于對照組患者，且觀察組患者的複髮轉移率顯著低于對照組患者，差異均具有統計學意義（P ＜0．05）。結論在腹腔鏡根治術後輔助化療治療，能提高患者的3年生存率，改善患者生命質量，併且能降低複髮轉移的風險。
목적：탐토결장암근치술보조화료대노년Ⅱ～Ⅲ기결장암환자적예후영향。방법장78례결장암환자안조시부화료분위관찰조38례화대조조40례。대조조환자지진행근치술，관찰조환자재근치술후진행보조화료。관찰2조환자적생명질량평개이급1년생존솔、3년생존솔화복발전이솔。결과대조조환자적 GLQI 총분、생리공능상태급증상여체정평분균현저저우치료전，차대조조환자치료후적 GLQI 총분、생리공능상태급증상여체정평분야명현저우관찰조환자，차이균구유통계학의의（P ＜0．05）。2조환자적1년생존솔비교무명현차별（P ＞0．05），단시관찰조환자적3년생존솔명현고우대조조환자，차관찰조환자적복발전이솔현저저우대조조환자，차이균구유통계학의의（P ＜0．05）。결론재복강경근치술후보조화료치료，능제고환자적3년생존솔，개선환자생명질량，병차능강저복발전이적풍험。
Objective To investigate the prognosis of adjuvant chemotherapy for stage Ⅱ-Ⅲ elderly colon cancer pa-tients after radical surgery.Methods 78 cases of colon cancer patients ,according to whether receive the chemotherapy ,were di-vided into the observation group (38 cases) and the control group (40 cases).The control group received only radical surgery ,the observation group received adjuvant chemotherapy after radical resection .Evaluation of quality of life,1-,3-year survival rates and recurrence rates of the 2 groups were observed.Results GLQI scores,physiological function and symptoms and signs scores of the control group were significantly lower after treatment ,and were significantly lower than those of the observation group ,the differences were statistically significant (P <0.05); 1-year survival rates of the 2 groups had no significant difference (P >0.05),but 3-year survival rate of the observation group was significantly higher than that of the control group ,and the recurrence rate of the observation group was significantly lower than that of the control group ,the differences were statistically significant (P<0.05).Conclusion Adjuvant chemotherapy after laparoscopic radical resection can improve 3-year survival rate,quality of life of patients,and decrease recurrence and metastasis .
