CAJ | 학술논문

目的：探讨干扰素辅助化疗方案在胆囊癌患者治疗中的临床作用。方法选择80例晚期胆囊癌患者，按照随机数字表法分为实验组和对照组，每组患者40例。对照组患者行常规化疗方案治疗，同期注射四氢叶酸100 mg／m 2、5－氟尿嘧啶700 mg／m 2、阿霉素60 mg／m 2、丝裂霉素10 mg／m 2。实验组患者在对照组患者治疗方案的基础上肌肉注射α－干扰素（剂量500万单位）。观察2组患者的近远期临床疗效；比较2组患者不良反应的差异。结果经过治疗，实验组患者 CR 8例，PR 13例，SD 15例，PD 4例，有效率显著高于对照组患者的17．5％，差异具有统计学意义（P ＜0．05）。经过随访，实验组患者1、2、3、4年的生存率分别为70．0％、52．5％、42．5％、37．5％，均显著高于对照组患者的远期疗效，差异具有统计学意义（P ＜0．05）。经过统计，实验组患者除脱发外，发热、白细胞减少、血小板减少、恶心／呕吐、肝功能损伤以及其他不良反应等的发生例数均明显少于对照组患者，具有较大差异性（P ＜0．05）。结论干扰素辅助化疗方案治疗晚期胆囊癌患者，不但能够显著提高患者的近远期临床疗效，而且能明显降低白细胞减少、血小板减少等不良反应的发生，是一种值得在临床上推广使用的治疗方案。
목적：탐토간우소보조화료방안재담낭암환자치료중적림상작용。방법선택80례만기담낭암환자，안조수궤수자표법분위실험조화대조조，매조환자40례。대조조환자행상규화료방안치료，동기주사사경협산100 mg／m 2、5－불뇨밀정700 mg／m 2、아매소60 mg／m 2、사렬매소10 mg／m 2。실험조환자재대조조환자치료방안적기출상기육주사α－간우소（제량500만단위）。관찰2조환자적근원기림상료효；비교2조환자불량반응적차이。결과경과치료，실험조환자 CR 8례，PR 13례，SD 15례，PD 4례，유효솔현저고우대조조환자적17．5％，차이구유통계학의의（P ＜0．05）。경과수방，실험조환자1、2、3、4년적생존솔분별위70．0％、52．5％、42．5％、37．5％，균현저고우대조조환자적원기료효，차이구유통계학의의（P ＜0．05）。경과통계，실험조환자제탈발외，발열、백세포감소、혈소판감소、악심／구토、간공능손상이급기타불량반응등적발생례수균명현소우대조조환자，구유교대차이성（P ＜0．05）。결론간우소보조화료방안치료만기담낭암환자，불단능구현저제고환자적근원기림상료효，이차능명현강저백세포감소、혈소판감소등불량반응적발생，시일충치득재림상상추엄사용적치료방안。
Objective To investigate the clinical effect of interferon on adjuvant chemotherapy in the treatment of gall -bladder cancer patients .Methods 80 patients with advanced gallbladder cancer ,according to the random number table,were di-vided into the experimental group and the control group ,each with 40 cases.The control group underwent conventional chemother -apy,leucovorin injection period 100 mg/m 2 ,5-fluorouracil 700 mg/m 2 ,doxorubicin 60 mg/m 2 ,mitomycin 10 mg/m 2 .The experi-mental group received intramuscular α-interferon (dose 5 million units) adjuvant chemotherapy based on the control group .Short-term and long-term clinical efficacy of the 2 groups were observed;adverse reactions between the 2 groups were compared.Results After treatment,the experimental group had 8 cases of CR,13 PR,15 SD,4 PD,the effective rat was significantly higher than that of the control group,17.5,there had significant difference (P <0.05);after a follow-up,1-,2-,3-,and 4-year survival rates in the experimental group were70.0%,52.5%,42.5%,and 37.5%,which were significantly higher than long -term efficacy in the con-trol group,there had statistical difference(P <0.05);in the experimental group,except hair loss,other adverse reactions such as fever,leukopenia,thrombocytopenia,nausea /vomiting,and liver damage were significantly less than those of the control group , there had statistical difference(P <0.05).Conclusion Interferon adjuvant chemotherapy for advanced gallbladder cancer can significantly improve short-term and long-term clinical efficacy,and significantly reduce neutropenia ,thrombocytopenia and other adverse reactions,it is worthy of clinical promotion.