CAJ | 학술논문

目的：探讨原发性睾丸类癌的临床病理学特点、免疫学表型、鉴别诊断以及诊治分析。方法采用光镜和免疫荧光染色对3例原发于睾丸类癌进行检测分析。结果3例睾丸原发性类癌组织界限清楚，质地中等硬度，切面呈灰黄色；癌细胞较小，呈柱状或多角形，胞质中等，形态大小均一；细胞质略嗜伊红颗粒形态，胞界模糊；细胞核居中央，圆形单一，染色质点状，未见核分裂象；肿瘤细胞排列呈条索状和巢状，一些组织内可见不规则较大的腺腔样结构；各癌巢间有纤细的纤维组织间隔，未见淋巴细胞浸润；细胞层次模糊，异型性不显著，周围见血管环绕；3例癌组织经免疫荧光染色显示：神经元特异性烯醇酶（NSE）、突触素（Syn）、和嗜铬素 A（CgA）呈阳性反应，而波形蛋白（Vimentin）呈阴性表达。结论睾丸原发性类癌临床罕见，特点尚缺乏统一性，需与其他睾丸肿瘤和转移性类癌相鉴别。
목적：탐토원발성고환유암적림상병이학특점、면역학표형、감별진단이급진치분석。방법채용광경화면역형광염색대3례원발우고환유암진행검측분석。결과3례고환원발성유암조직계한청초，질지중등경도，절면정회황색；암세포교소，정주상혹다각형，포질중등，형태대소균일；세포질략기이홍과립형태，포계모호；세포핵거중앙，원형단일，염색질점상，미견핵분렬상；종류세포배렬정조색상화소상，일사조직내가견불규칙교대적선강양결구；각암소간유섬세적섬유조직간격，미견림파세포침윤；세포층차모호，이형성불현저，주위견혈관배요；3례암조직경면역형광염색현시：신경원특이성희순매（NSE）、돌촉소（Syn）、화기락소 A（CgA）정양성반응，이파형단백（Vimentin）정음성표체。결론고환원발성유암림상한견，특점상결핍통일성，수여기타고환종류화전이성유암상감별。
Objective To investigate clinicopathological features of primary testicular carcinoid tumor and diagnosis and treatment.Methods Light microscopy and immunofluorescence staining were used to detect 3 cases of primary testicular carci-noid tumor.Results 3 cases of primary carcinoid tumors had clear dividing line ,tender swelling of the testis,and luidity of sec-tion.Its cells were small,columnar or polygon,and its cytoplasm medium with uniform size ,stippling chromatin and eosinophilic granular cytoplasm.The nucleus was located in center ,round and single,chromatin of punctiform,without mitosis.Tumor cells were arranged as cords and nested compilation .There were some large and irregular adenoid structures .Fiber spacing was seen a-mong tumor cells and without lymphocytic infiltration .The cellular level was obscure with indistinctive atypia and vascular circle . Immunofluorescence staining showed that NSE ,Syn and CgA were positively expressed ,Vimentin was negatively expressed .Con-clusion Primary testicular carcinoid tumor is extremely rare in the clinic ,without the unity of its character ,and it has to be dif-ferentiated from other orchioncuses and metastatic carcinoid tumor .