CAJ | 학술논문

目的探讨伴有抑郁症状的精神分裂症患者的血清皮质醇（ COR）及甲状腺功能特征。方法采用免疫化学发光法检测伴有抑郁症状的精神分裂症患者（ A组）58例、不伴有抑郁症状的精神分裂症患者（ B组）57例、抑郁症患者（ C组）58例治疗前及治疗后6周的COR及甲状腺功能，以健康对照组（ D组）60例为参考。结果 A、B两组的COR水平均高于D组（P﹤0.05）。A、C两组TT4、FT3及TSH与D组比较差异有统计学意义（P﹤0.05）。其余指标四组间比较差异均无统计学意义。治疗后A、C两组FT4较治疗前低（ P﹤0.05）。B组TT4治疗前后差异有统计学意义（ P﹤0.05）。ABC三组患者治疗后的有效率分别为84.5%、82.4%、79.3%，组间比较差异无统计学意义（P﹥0.05）。治疗后三组COR水平均下降，与对照组比较差异均无统计学意义（P﹥0.05）。结论伴有抑郁症状的精神分裂症患者甲状腺功能存在一定变化，甲状腺激素水平可能与抑郁症状有关。
목적탐토반유억욱증상적정신분렬증환자적혈청피질순（ COR）급갑상선공능특정。방법채용면역화학발광법검측반유억욱증상적정신분렬증환자（ A조）58례、불반유억욱증상적정신분렬증환자（ B조）57례、억욱증환자（ C조）58례치료전급치료후6주적COR급갑상선공능，이건강대조조（ D조）60례위삼고。결과 A、B량조적COR수평균고우D조（P﹤0.05）。A、C량조TT4、FT3급TSH여D조비교차이유통계학의의（P﹤0.05）。기여지표사조간비교차이균무통계학의의。치료후A、C량조FT4교치료전저（ P﹤0.05）。B조TT4치료전후차이유통계학의의（ P﹤0.05）。ABC삼조환자치료후적유효솔분별위84.5%、82.4%、79.3%，조간비교차이무통계학의의（P﹥0.05）。치료후삼조COR수평균하강，여대조조비교차이균무통계학의의（P﹥0.05）。결론반유억욱증상적정신분렬증환자갑상선공능존재일정변화，갑상선격소수평가능여억욱증상유관。
Objective To discuss the serum cortisol and thyroid function features of depressive disorder in schizophrenia. Meth-ods Immunology chemiluminescence method was applied to detecte the serum cortisol and thyroid function features of 58 patients with schizophrenia( group A),57 schizophrenia without depressive disorder( group B),and 58 depressed patients( group C). The compra=sion was ketween pre therapy and 6 weed posttreatment. with 60 health volunteers( group D). Results The COR levels of group A and B were significantly higher than group D(P﹤0.05). There were significant difference ketween group A and C in TT4,FT3 and TSH(P﹤0. 05). The FT4 of group A and C were lower than that of after treatment. There was significant difference ketween pre-treatment and post-treatment in group B(P ﹤0. 05). The effective rate of treatment of the three groups were 84. 5%,82. 4%, 79. 3%. The difference among the three groups were not significant(P﹥0. 05). COR of three groups had descend after treatment,kut there was no significant difference ketween the three groups and the control group(P﹥0. 05). Conclusion Thyroid function of de=pressive disorder in schizophrenic may have some changes. Depression is related to the level of thyroxine hormone.