实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
6期
834-836
,共3页
放射治疗%化疗%小细胞肺癌
放射治療%化療%小細胞肺癌
방사치료%화료%소세포폐암
Radiation therapy%Chemotherapy treatment%Small cell lung cancer
目的：探讨与比较放疗与单纯化疗治疗小细胞肺癌的疗效与安全性。方法将180例小细胞肺癌患者随机分为放疗组与化疗组，每组各90例，放疗组采用常规放射治疗与三维适形放射治疗，化疗组采用 EP、CE、CAO 化疗方案，观察与比较两组患者的临床治疗效果与不良反应发生状况。结果放疗组治疗总有效率（RR）与化疗组基本接近，放疗组疾病控制率（DCR）稍高于化疗组，均无统计学差异（χ2＝0．927，χ2＝1．327，P ＞0．05），放疗组1年生存例数、2年生存例数、3年生存例数均显著多于化疗组，组间具统计学差异（P ＜0．05），组间各不良反应发生率无统计学差异（P ＜0．05）。结论放射治疗与单纯化疗的治疗总有效率和疾病控制率基本一致，两组患者的不良反应轻，均可耐受，而放射治疗较单纯化疗可延长小细胞肺癌患者的生存期及提高生存率。
目的：探討與比較放療與單純化療治療小細胞肺癌的療效與安全性。方法將180例小細胞肺癌患者隨機分為放療組與化療組，每組各90例，放療組採用常規放射治療與三維適形放射治療，化療組採用 EP、CE、CAO 化療方案，觀察與比較兩組患者的臨床治療效果與不良反應髮生狀況。結果放療組治療總有效率（RR）與化療組基本接近，放療組疾病控製率（DCR）稍高于化療組，均無統計學差異（χ2＝0．927，χ2＝1．327，P ＞0．05），放療組1年生存例數、2年生存例數、3年生存例數均顯著多于化療組，組間具統計學差異（P ＜0．05），組間各不良反應髮生率無統計學差異（P ＜0．05）。結論放射治療與單純化療的治療總有效率和疾病控製率基本一緻，兩組患者的不良反應輕，均可耐受，而放射治療較單純化療可延長小細胞肺癌患者的生存期及提高生存率。
목적：탐토여비교방료여단순화료치료소세포폐암적료효여안전성。방법장180례소세포폐암환자수궤분위방료조여화료조，매조각90례，방료조채용상규방사치료여삼유괄형방사치료，화료조채용 EP、CE、CAO 화료방안，관찰여비교량조환자적림상치료효과여불량반응발생상황。결과방료조치료총유효솔（RR）여화료조기본접근，방료조질병공제솔（DCR）초고우화료조，균무통계학차이（χ2＝0．927，χ2＝1．327，P ＞0．05），방료조1년생존례수、2년생존례수、3년생존례수균현저다우화료조，조간구통계학차이（P ＜0．05），조간각불량반응발생솔무통계학차이（P ＜0．05）。결론방사치료여단순화료적치료총유효솔화질병공제솔기본일치，량조환자적불량반응경，균가내수，이방사치료교단순화료가연장소세포폐암환자적생존기급제고생존솔。
Objective To investigate the efficacy and safety of radiation therapy and chemotherapy for small cell lung cancer.Methods 180 small cell lung cancer patients were randomly divided into radiotherapy group and chemotherapy group , each with 90 cases,radiotherapy group received conventional radiotherapy and three -dimensional conformal radiation therapy , chemotherapy group received EP ,CE,CAO chemotherapy,clinical effect and adverse reactions of the 2 groups were observed and compared.Results The total effective rate of radiotherapy group was close to that of the chemotherapy group ,and disease control rate(DCR)of radiotherapy group was slightly higher than that of the chemotherapy group ,there was no significant difference (χ2 =0.927,χ2 =1.327,P >0.05),1-,2-,3-year survival rates in radiotherapy group was significantly higher than those of the chemo -therapy group,there was significant difference between the 2 groups (P <0.05),incidence of adverse reactions between the 2 groups had no significant difference (P >0.05).Conclusion Total efficiency and disease control rate of chemotherapy and ra -diotherapy treatment basically are same ,adverse reactions in the 2 groups are mild and can be tolerated,and radiation therapy can prolong survival time and survival rate of patients with small cell lung cancer .
