CAJ | 학술논문

目的：对小儿迁延性慢性腹泻病中检测过敏原值的变化,以明确和分析其发生的原因、临床表现、诊治及预后,为类似病例的防治提供参考。方法我院儿科2012年1月~2014年3月共收治101例原因不明迁延性慢性腹泻患儿,根据食物 IgG 过敏原特异性检测结果是否阳性分为两组,82例阳性患儿为过敏组,19例阴性患儿为非过敏组,比较两组临床表现及预后。结果两组患儿肠道菌群、便红细胞、便白细胞、便常规、便脂肪球、便潜血异常率比较差异无统计学意义(P >0.05)。血清总 IgE 水平、总蛋白、白蛋白、血中性粒细胞含量比较差异无统计学意义(P >0.05)。过敏组食物 IgG 抗体阳性率明显高于非过敏组(P <0.05)。过敏组食物过敏原 IgG 抗体平均浓度为(5479±1280)mg/L,明显高于非过敏组(P <0.001)。过敏组总有效率为91.46%,非过敏组总有效率为52.63%(P <0.001)。结论食物过敏是导致小儿迁延性慢性腹泻的主要原因之一,其临床表现及相关指标与非食物过敏患儿相似,过敏原检测和回避过敏原诊断性治疗有助于明确诊断。
목적：대소인천연성만성복사병중검측과민원치적변화,이명학화분석기발생적원인、림상표현、진치급예후,위유사병례적방치제공삼고。방법아원인과2012년1월~2014년3월공수치101례원인불명천연성만성복사환인,근거식물 IgG 과민원특이성검측결과시부양성분위량조,82례양성환인위과민조,19례음성환인위비과민조,비교량조림상표현급예후。결과량조환인장도균군、편홍세포、편백세포、편상규、편지방구、편잠혈이상솔비교차이무통계학의의(P >0.05)。혈청총 IgE 수평、총단백、백단백、혈중성립세포함량비교차이무통계학의의(P >0.05)。과민조식물 IgG 항체양성솔명현고우비과민조(P <0.05)。과민조식물과민원 IgG 항체평균농도위(5479±1280)mg/L,명현고우비과민조(P <0.001)。과민조총유효솔위91.46%,비과민조총유효솔위52.63%(P <0.001)。결론식물과민시도치소인천연성만성복사적주요원인지일,기림상표현급상관지표여비식물과민환인상사,과민원검측화회피과민원진단성치료유조우명학진단。
Objective To measure the allergen changes in children with persistent and chronic diarrhea and to understand and analyze the disease causes,clinical manifestation,treatment and prognosis,so as to pro-vide references for prevention and treatment of similar cases. Methods January 2012~March 2014 a total of 101 children with unexplained persistent and chronic diarrhea were cared at our hospital,according to whether the food allergen specific IgG detection results was positive or not,patients were divided into two groups,82 cases of children with positive allergen group,1 9 patients with negative allergen group,compared of clinical manifestation and prognosis between the two groups. Results Compared of the abnormal rates of intestinal flora,fecal red cells,fecal white cells,stool routine,fecal fat globules and fecal occult blood between the two groups of children showed no statistical difference (P >0.05).Group-comparison of total serum IgE levels, total protein,albumin,blood neutrophil content yielded no statistical difference (P >0.05).The positive rate of food IgG antibody of allergic group was significantly higher than that of non allergic group (P <0.05).The allergic group had higher average concentration of food allergen IgG antibody (5479±1280)mg/L than that of non allergic group(P <0.001).The allergic group had a total efficiency rate of 91.46%,and the non allergic group had a total effective rate of 52.63% (P <0.001). Conclusion Food allergy is one of the major reasons resulting in children with persistent and chronic diarrhea,the clinical manifestations and related index are simi-lar to the children with non food allergies,detection of allergens and allergen avoidance diagnostic treatment are helpful to the diagnosis.