实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
6期
812-814
,共3页
组织%宫颈癌%血清%VEGF-C%相关性
組織%宮頸癌%血清%VEGF-C%相關性
조직%궁경암%혈청%VEGF-C%상관성
Tissue%Cervical cancer%Serum%VEGF-C%Relevance
目的：探析老年宫颈癌患者组织和血清中血管内皮细胞生长因子（VEGF－C）的表达及其相关性。方法将入选的60例老年宫颈癌患者作为观察对象，其中淋巴转移和非淋巴转移者各30例；入选同期30例老年宫颈上皮内瘤变（CIN）患者和30例老年健康人群作为对照。采用免疫组化（SP）法检测组织中 VEGF－C 的表达，采用双抗体夹心酶联吸附免疫（ELISA）法检测血清中 VEGF－C 的浓度，并采用 Pearson 相关分析研究 VEGF－C 在组织和血清中的相关性。结果宫颈癌淋巴转移组组织 VEGF－C 阳性表达率93．3％（28／30）最高，吸光度（32865．4±5927．4）最高，血清中 VEGF－C 浓度（13845．2±1228．6）pg／ml 最高，其次为宫颈癌非淋巴转移组和 CIN 对照组，正常对照组最低，组间差异均具有统计学意义（P 均＜0．05）；组织和血清中的 VEGF－C 呈正相关性，相关系数γ＝0．723。结论老年宫颈癌患者组织和血清中 VEGF－C 均显著升高，且二者呈正相关性。
目的：探析老年宮頸癌患者組織和血清中血管內皮細胞生長因子（VEGF－C）的錶達及其相關性。方法將入選的60例老年宮頸癌患者作為觀察對象，其中淋巴轉移和非淋巴轉移者各30例；入選同期30例老年宮頸上皮內瘤變（CIN）患者和30例老年健康人群作為對照。採用免疫組化（SP）法檢測組織中 VEGF－C 的錶達，採用雙抗體夾心酶聯吸附免疫（ELISA）法檢測血清中 VEGF－C 的濃度，併採用 Pearson 相關分析研究 VEGF－C 在組織和血清中的相關性。結果宮頸癌淋巴轉移組組織 VEGF－C 暘性錶達率93．3％（28／30）最高，吸光度（32865．4±5927．4）最高，血清中 VEGF－C 濃度（13845．2±1228．6）pg／ml 最高，其次為宮頸癌非淋巴轉移組和 CIN 對照組，正常對照組最低，組間差異均具有統計學意義（P 均＜0．05）；組織和血清中的 VEGF－C 呈正相關性，相關繫數γ＝0．723。結論老年宮頸癌患者組織和血清中 VEGF－C 均顯著升高，且二者呈正相關性。
목적：탐석노년궁경암환자조직화혈청중혈관내피세포생장인자（VEGF－C）적표체급기상관성。방법장입선적60례노년궁경암환자작위관찰대상，기중림파전이화비림파전이자각30례；입선동기30례노년궁경상피내류변（CIN）환자화30례노년건강인군작위대조。채용면역조화（SP）법검측조직중 VEGF－C 적표체，채용쌍항체협심매련흡부면역（ELISA）법검측혈청중 VEGF－C 적농도，병채용 Pearson 상관분석연구 VEGF－C 재조직화혈청중적상관성。결과궁경암림파전이조조직 VEGF－C 양성표체솔93．3％（28／30）최고，흡광도（32865．4±5927．4）최고，혈청중 VEGF－C 농도（13845．2±1228．6）pg／ml 최고，기차위궁경암비림파전이조화 CIN 대조조，정상대조조최저，조간차이균구유통계학의의（P 균＜0．05）；조직화혈청중적 VEGF－C 정정상관성，상관계수γ＝0．723。결론노년궁경암환자조직화혈청중 VEGF－C 균현저승고，차이자정정상관성。
Objective To study the VEGF-C expression in tissues and serum of elderly patients with cervical cancer and their relevance.Methods 60 elderly patients with cervical cancer were chosen as research objects ,including 30 cases with lym-phatic metastasis and 30 cases without lymphatic metastasis.30 elderly patients with CIN and 30 elderly healthy patients were chosen as the control group.SP method was adopted to detect expression of VEGF -C in tissues,and ELISA method was adopted to detect VEGF concentration in serum .Pearson relevance analysis was adopted to study the relevance of VEGF -C in tissues and ser-um.Results Positive expression rate of VEGF-C in cervical cancer tissues with lymphatic metastasis was 93.3% (28/30),ab-sorbancy was (32865.4 ±5927.4),and serum VEGF-C level was (13845.2 ±1228.6) pg/ml which was the highest,secondly was cervical cancer without lymphatic metastasis and CIN control group ,and healthy control group was the lowest (all P <0.05). There was positive relevance between VEGF -C in tissues and serum,and the correlation index was γ=0.723.Conclusion VEGF-C in tissues and serum of elderly patients with cervical cancer both rise obviously and they are positively related .
