CAJ | 학술논문

目的：探讨肿瘤周边区微淋巴管密度对子宫内膜癌患者生存状况的影响。方法选取子宫内膜癌患者115例，采用免疫组化 SP 法检测 LYVE－1、HIF－1α、VEGF－C 的表达水平，低倍镜下分别对子宫内膜癌组织肿瘤边缘（P－LVD）和中心区阳性淋巴管密集区域（I－LVD）。结果P－LVD 与肿瘤分化程度、FIGO 分期和淋巴结转移是否有关（P ＜0．05），I－LVD 与所有参数无关（P ＞0．05）；HIF－1α和 VEGF－C 阳性表达率分别为76．19％和52．38％；P－LVD、病理类型、FIGO 分期为子宫内膜癌患者预后的独立危险因素（P ＜0．05）。结论HIF－1α和 VEGF－C 在子宫内膜癌患者中表达较高；影响子宫内膜癌患者的独立危险因素有 P－LVD、病理类型和 FIGO 分期。
목적：탐토종류주변구미림파관밀도대자궁내막암환자생존상황적영향。방법선취자궁내막암환자115례，채용면역조화 SP 법검측 LYVE－1、HIF－1α、VEGF－C 적표체수평，저배경하분별대자궁내막암조직종류변연（P－LVD）화중심구양성림파관밀집구역（I－LVD）。결과P－LVD 여종류분화정도、FIGO 분기화림파결전이시부유관（P ＜0．05），I－LVD 여소유삼수무관（P ＞0．05）；HIF－1α화 VEGF－C 양성표체솔분별위76．19％화52．38％；P－LVD、병리류형、FIGO 분기위자궁내막암환자예후적독립위험인소（P ＜0．05）。결론HIF－1α화 VEGF－C 재자궁내막암환자중표체교고；영향자궁내막암환자적독립위험인소유 P－LVD、병리류형화 FIGO 분기。
Objective To investigate the influence of peritumoral micro -lymphatic vessel density on prognosis of endom -etrial carcinoma.Methods 115 cases of endometrial carcinoma were selected .The level of LYVE-1,HIF-1αand VEGF-C were determined using the immunohistochemical SP method .Peritumoral lymphatic vessel density (P-LVD) and intratumoral lymphatic vessel density (I-LVD) were observed by low magnification microscope .Results P-LVD was closely associated with the degree of differentiation,FIGO staging,with or without lymph node metastasis,and I-LVD was not related with any parameters .The posi-tive rates of HIF-1αand VEGF-C were 76.19%and 52.38%,respectively.P-LVD,pathological type and FIGO staging were inde -pendent risk factor for prognosis (P <0.05).Conclusion HIF-1αand VEGF-C are highly-expressed in endometrial carcinoma , FIGO staging,with or without lympho node metastasis ;P-LVD,pathological type and FIGO staging are independent risk factor for prognosis.