CAJ | 학술논문

目的：探讨健康体检人群中慢性肾脏疾病(chronic kidney disease，CKD)的患病情况及其相关危险因素。方法：2008年1月至2011年6月在中南大学湘雅三医院健康管理中心进行健康体检并且资料完整的年龄20岁以上的体检人群为研究对象，分别记录受检者CKD及相关危险因素的检测结果和问卷调查的结果。对CKD的相关危险因素分析采用多因素logistic回归分析。CKD的判断标准为微量白蛋白尿和(或)血尿和(或)肾功能下降[估算肾小球滤过率(eGFR)<60 mL/(min.1.73 m2)]。以简化的肾脏病膳食改良(modiifcation of diet in renal disease，MDRD)公式计算eGFR。结果：在最终入选的5708例体检人群中白蛋白尿、肾功能下降和血尿的检出率分别为25.0%，1.7%和1.1%，总CKD的检出率为25.6%。CKD1~5期的检出率分别为17.8%，6.7%，1.1%，0和0。多因素logistic回归分析显示糖尿病、高血压、高胆固醇血症、男性、年龄和吸烟是CKD的独立危险因素，运动量增加是CKD的保护因素。结论：健康体检是筛查CKD的重要途径。戒烟，控制血糖、血压、血脂及增加运动量可能有利于降低CKD的发病率。
목적：탐토건강체검인군중만성신장질병(chronic kidney disease，CKD)적환병정황급기상관위험인소。방법：2008년1월지2011년6월재중남대학상아삼의원건강관리중심진행건강체검병차자료완정적년령20세이상적체검인군위연구대상，분별기록수검자CKD급상관위험인소적검측결과화문권조사적결과。대CKD적상관위험인소분석채용다인소logistic회귀분석。CKD적판단표준위미량백단백뇨화(혹)혈뇨화(혹)신공능하강[고산신소구려과솔(eGFR)<60 mL/(min.1.73 m2)]。이간화적신장병선식개량(modiifcation of diet in renal disease，MDRD)공식계산eGFR。결과：재최종입선적5708례체검인군중백단백뇨、신공능하강화혈뇨적검출솔분별위25.0%，1.7%화1.1%，총CKD적검출솔위25.6%。CKD1~5기적검출솔분별위17.8%，6.7%，1.1%，0화0。다인소logistic회귀분석현시당뇨병、고혈압、고담고순혈증、남성、년령화흡연시CKD적독립위험인소，운동량증가시CKD적보호인소。결론：건강체검시사사CKD적중요도경。계연，공제혈당、혈압、혈지급증가운동량가능유리우강저CKD적발병솔。
Objective: To investigate chronic kidney disease (CKD) and its risk factors in people receiving physical examination. Methods: hTis retrospective study included people over 20 years old who had physical examination in the Health Management Center of Third Xiangya Hospital from Janurary 2008 to June 2011. CKD and its risk factors as well as questionnaire were recorded. hTe risk factors were analyzed by multivariate logistic analysis. CKD was deifned by kidney damage (microalbuminuria≥30 mg/L) and/or hematuria and/or reduced kidney function [evaluate glomerular ifltration rate (eGFR)<60mL/(min.1.73 m2)]. We counted eGFR according to the modiifcation of diet in renal disease (MDRD). Results: A total of 5 708 physical examination reports were included. The detection rate of albuminuria, reduced renal function and hematuria was 25.0%, 1.7% and 1.1%. hTe detection rate of CKD was 25.6%, and detection rate of CKD stage 1-5 was 17.8%, 6.7%, 1.1%, 0 and 0, respectively. Multivariate logistic analysis indicated that diabetes mellitus, hypertension, hypercholesterolemia, male, age, and smoking were the risk factors for CKD. Increasing physical activity was the protective factor against CKD. Conclusion: High prevalence of CKD in people receiving physical examination is found in Changsha, especially stage 1 and 2 CKD. Physical examination is important to screen CKD. Stopping smoking, control of blood glucose, blood pressure, blood lipids and increasing physical activity may help reduce the prevalence of CKD.