中南大学学报（医学版）
中南大學學報（醫學版）
중남대학학보（의학판）
JOURNAL OF CENTRAL SOUTH UNIVERSITY (MEDICAL SCIENCES)
2014年
4期
389-394
,共6页
脂肪细胞因子%网膜素-1%骨密度
脂肪細胞因子%網膜素-1%骨密度
지방세포인자%망막소-1%골밀도
adipocytokines%omentin-1%bone mineral density
目的：探讨绝经后女性血清网膜素-1浓度与骨密度的关系，进一步了解脂肪组织对骨密度的影响。方法：运用双能X线骨扫描仪(DEXA)测定此336名受试人群全身总体骨密度、腰椎正位、左侧前臂、髋部总体、左侧股骨颈、Ward’s三角区、左侧股骨大转子及转子内骨密度及体成份，运用酶联免疫吸附试验(ELISA)测定血清脂肪因子(网膜素，脂联素，瘦素，抵抗素，内脏脂肪素，apelin)浓度。结果：超重及肥胖组较正常体重组有更高的总髋、股骨颈、转子内骨密度；血清网膜素-1与腰椎、股骨颈、股骨大转子、转子内、总髋、Ward’s三角区BMD呈负相关(r=-0.159，-0.259，-0.233，-0.243，-0.247，-0.112)，校正年龄、BMI及体脂后，网膜素-1与各部位BMD相关无显著性。逐步多元线性回归分析，总瘦重、绝经年限及雌激素是总体及各部位骨密度的独立相关因素，其变化分别可以解释12.2%~13.7%，6.9%~13.1%，0.9%~1.7%的变异。血清脂联素是腰椎、总髋及总体骨密度的独立相关因素。结论：绝经后女性血清网膜素-1与各部位及总体骨密度无显著相关；雌激素、绝经年限、瘦重是绝经后女性各部位及总体骨密度的独立预测因子。血清脂联素是腰椎、总髋及总体骨密度的独立预测因子。
目的：探討絕經後女性血清網膜素-1濃度與骨密度的關繫，進一步瞭解脂肪組織對骨密度的影響。方法：運用雙能X線骨掃描儀(DEXA)測定此336名受試人群全身總體骨密度、腰椎正位、左側前臂、髖部總體、左側股骨頸、Ward’s三角區、左側股骨大轉子及轉子內骨密度及體成份，運用酶聯免疫吸附試驗(ELISA)測定血清脂肪因子(網膜素，脂聯素，瘦素，牴抗素，內髒脂肪素，apelin)濃度。結果：超重及肥胖組較正常體重組有更高的總髖、股骨頸、轉子內骨密度；血清網膜素-1與腰椎、股骨頸、股骨大轉子、轉子內、總髖、Ward’s三角區BMD呈負相關(r=-0.159，-0.259，-0.233，-0.243，-0.247，-0.112)，校正年齡、BMI及體脂後，網膜素-1與各部位BMD相關無顯著性。逐步多元線性迴歸分析，總瘦重、絕經年限及雌激素是總體及各部位骨密度的獨立相關因素，其變化分彆可以解釋12.2%~13.7%，6.9%~13.1%，0.9%~1.7%的變異。血清脂聯素是腰椎、總髖及總體骨密度的獨立相關因素。結論：絕經後女性血清網膜素-1與各部位及總體骨密度無顯著相關；雌激素、絕經年限、瘦重是絕經後女性各部位及總體骨密度的獨立預測因子。血清脂聯素是腰椎、總髖及總體骨密度的獨立預測因子。
목적：탐토절경후녀성혈청망막소-1농도여골밀도적관계，진일보료해지방조직대골밀도적영향。방법：운용쌍능X선골소묘의(DEXA)측정차336명수시인군전신총체골밀도、요추정위、좌측전비、관부총체、좌측고골경、Ward’s삼각구、좌측고골대전자급전자내골밀도급체성빈，운용매련면역흡부시험(ELISA)측정혈청지방인자(망막소，지련소，수소，저항소，내장지방소，apelin)농도。결과：초중급비반조교정상체중조유경고적총관、고골경、전자내골밀도；혈청망막소-1여요추、고골경、고골대전자、전자내、총관、Ward’s삼각구BMD정부상관(r=-0.159，-0.259，-0.233，-0.243，-0.247，-0.112)，교정년령、BMI급체지후，망막소-1여각부위BMD상관무현저성。축보다원선성회귀분석，총수중、절경년한급자격소시총체급각부위골밀도적독립상관인소，기변화분별가이해석12.2%~13.7%，6.9%~13.1%，0.9%~1.7%적변이。혈청지련소시요추、총관급총체골밀도적독립상관인소。결론：절경후녀성혈청망막소-1여각부위급총체골밀도무현저상관；자격소、절경년한、수중시절경후녀성각부위급총체골밀도적독립예측인자。혈청지련소시요추、총관급총체골밀도적독립예측인자。
Objective: To determine the relationship between serum omentin-1 concentration and bone mineral desity in postmenopausal women, and the adipose influence of tissue on bone mineral density (BMD). Methods: BMD values of 336 participants were measured by dual-energy-x-ray absorptiometry (DEXA) at various skeletal sites: the anteroposterior spine, femeral neck, total hip (T-hip) and total body BMD (TBMD). Body compositions including lean tissue mass (LTM) and body fat mass (FBM) were measured by DEXA. hTe plasma concentrations of adipocytokines (omentin-1, adiponectin,leptin,resistin,visfatin, andapelin) were measured by ELISA. Results: hTe overweight and obese groups had higher T-hip,femerol neck, intertrochanter BMDthan the nomal weight group. Plasma omentin-1 was negatively correlated with anteroposterior spine, femeral neck, trochanter, intertrochanter, T-hip and Ward’s BMD, after adjustment for age, BMI and fat body mass, and the correlation was not significant. Multiple stepwise regression anlysis revealed that lean body mass, menopause duration and estrogen level were the most important variables affecting the BMD and each explained 12.2%–13.7%, 6.9%–13.1%, 0.9%–1.7% of the variance. Serum adiponectin was independently associated with T-hip, lumbar spine and total BMD. Conclusion: Plasma omentin-1 is not significantly correlated with BMD in postmenopausal women. Lean body mass, menopause duration and estrogen level are the most important variables affecting the BMD. Serum adiponectin is an independent predictor of T-hip, lumbar spine and total BMD.
