重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
14期
1888-1890
,共3页
刘强%邓华聪%李永玲%何辉%代薇%林小琴
劉彊%鄧華聰%李永玲%何輝%代薇%林小琴
류강%산화총%리영령%하휘%대미%림소금
糖尿病 ,2型%氧化应激%血管内皮功能%银丹心脑通软胶囊
糖尿病 ,2型%氧化應激%血管內皮功能%銀丹心腦通軟膠囊
당뇨병 ,2형%양화응격%혈관내피공능%은단심뇌통연효낭
diabetes mellitus,type 2%oxidative stress%endothelial function%Yindan Xinnaotong Soft Capsule
目的:研究银丹心脑通软胶囊对2型糖尿病氧化应激及血管内皮功能的影响。方法86例2型糖尿病患者按照随机数字表法分成常规降糖治疗组(常规组,n=40)和银丹心脑通软胶囊治疗组(银丹心脑通组,n=46)。常规组患者在控制饮食、运动等基础上给予降糖治疗使血糖连续达标12周,银丹心脑通组在常规治疗血糖达标基础上加用银丹心脑通软胶囊(每次1.2 g ,每日3次)连续治疗12周。检测两组患者治疗前后血脂、丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、内皮素(ET)等相关因素变化,应用超声检测肱动脉血流介导的内皮依赖性舒张功能(FMD)和非内皮依赖性血管舒张功能(NMD)。结果治疗12周后两组患者血浆总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL‐C)、MDA、ET 较治疗前均有明显下降,高密度脂蛋白胆固醇(HDL‐C)、SOD、NO、FMD则较治疗前升高(P<0.05);而且银丹心脑通组治疗后上述各项指标与常规组治疗后比较也有显著变化(P<0.05)。结论银丹心脑通软胶囊可下调2型糖尿病氧化应激,调节糖尿病脂代谢异常,明显改善损伤的血管内皮功能。
目的:研究銀丹心腦通軟膠囊對2型糖尿病氧化應激及血管內皮功能的影響。方法86例2型糖尿病患者按照隨機數字錶法分成常規降糖治療組(常規組,n=40)和銀丹心腦通軟膠囊治療組(銀丹心腦通組,n=46)。常規組患者在控製飲食、運動等基礎上給予降糖治療使血糖連續達標12週,銀丹心腦通組在常規治療血糖達標基礎上加用銀丹心腦通軟膠囊(每次1.2 g ,每日3次)連續治療12週。檢測兩組患者治療前後血脂、丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、內皮素(ET)等相關因素變化,應用超聲檢測肱動脈血流介導的內皮依賴性舒張功能(FMD)和非內皮依賴性血管舒張功能(NMD)。結果治療12週後兩組患者血漿總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL‐C)、MDA、ET 較治療前均有明顯下降,高密度脂蛋白膽固醇(HDL‐C)、SOD、NO、FMD則較治療前升高(P<0.05);而且銀丹心腦通組治療後上述各項指標與常規組治療後比較也有顯著變化(P<0.05)。結論銀丹心腦通軟膠囊可下調2型糖尿病氧化應激,調節糖尿病脂代謝異常,明顯改善損傷的血管內皮功能。
목적:연구은단심뇌통연효낭대2형당뇨병양화응격급혈관내피공능적영향。방법86례2형당뇨병환자안조수궤수자표법분성상규강당치료조(상규조,n=40)화은단심뇌통연효낭치료조(은단심뇌통조,n=46)。상규조환자재공제음식、운동등기출상급여강당치료사혈당련속체표12주,은단심뇌통조재상규치료혈당체표기출상가용은단심뇌통연효낭(매차1.2 g ,매일3차)련속치료12주。검측량조환자치료전후혈지、병이철(MDA)、초양화물기화매(SOD)、일양화담(NO)、내피소(ET)등상관인소변화,응용초성검측굉동맥혈류개도적내피의뢰성서장공능(FMD)화비내피의뢰성혈관서장공능(NMD)。결과치료12주후량조환자혈장총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL‐C)、MDA、ET 교치료전균유명현하강,고밀도지단백담고순(HDL‐C)、SOD、NO、FMD칙교치료전승고(P<0.05);이차은단심뇌통조치료후상술각항지표여상규조치료후비교야유현저변화(P<0.05)。결론은단심뇌통연효낭가하조2형당뇨병양화응격,조절당뇨병지대사이상,명현개선손상적혈관내피공능。
Objective To investigate the effects of Yindan Xinnaotong Soft Capsule on oxidative stress and vascular endothe‐lial function in the patients with type 2 diabetes mellitus(T2DM ) .Methods A total of 86 patients with T2DM were randomly di‐vided into the routine glucose‐reducing group(routine group ,40 cases) and the Yindan Xinnaotong Soft Capsule group(Yindan Xin‐naotong group ,46 cases) .On the basis of diet control and exercise ,the routine group was given the glucose‐reducing therapy for blood glucose reaching the standard for 12 successive weeks ,while on the basis of blood glucose reaching the standard by the rou‐tine therapy ,the Yindan Xinnaotong group was added with Yindan Xinnaotong Soft Capsule ,1 .2 g per time ,3 times daily for 12 successive weeks .The changes of blood lipids ,MDA ,SOD ,NO and ET were determined before treatment and after 12‐week treat‐ment .The flow mediated endothelium‐dependent diastolic function (FMD) and non‐flow mediated endothelium‐dependent diastolic function (NMD) in brachial artery were simultaneously detected using ultrasonography .Results After 12 weeks of treatment ,the levels of TC ,TG ,LDL‐C ,MDA and ET in the two group were obviously decreased compared with before treatment ,the levels of HDL‐C ,SOD ,NO and FMD in both groups were increased (P<0 .05);moreover the above indexes after treatment in the Yindan Xinnaotong group had significant changes compared with the routine group (P<0 .05) .Conclusion Yindan Xinnaotong Soft Cap‐sule can down‐regulate oxidative stress and regulate the lipid metabolic abnormality and obviously improve the injured vascular en‐dothelial function in T2DM .