CAJ | 학술논문

目的：探讨妊娠期肝内胆汁淤积症（ICP）患者总胆汁酸（TBA）、甘胆酸（CG）、肝生化指标、肿瘤坏死因子‐α（TNF‐α）对产妇和围生儿的影响。方法对2012年1月至2013年12月收治的164例IC P患者的临床资料进行回顾性分析，放射免疫法分析TBA、CG、TNF‐α，生化仪分析肝功能。结果 ICP患者较健康产妇的TBA、CG、总胆红素（TBIL）、直接胆红素（DBIL）、丙氨酸氨基转移酶（ALT）均有增加，即肝功能受到损伤，血清TNF‐α表达增加，重度ICP患者较轻度ICP患者上述指标升高，产后出血率增加，Apgar评分降低（P＜0．05）。结论 ICP系高危妊娠，TNF‐α和CG、TBA共同反映ICP的病情严重程度。
목적：탐토임신기간내담즙어적증（ICP）환자총담즙산（TBA）、감담산（CG）、간생화지표、종류배사인자‐α（TNF‐α）대산부화위생인적영향。방법대2012년1월지2013년12월수치적164례IC P환자적림상자료진행회고성분석，방사면역법분석TBA、CG、TNF‐α，생화의분석간공능。결과 ICP환자교건강산부적TBA、CG、총담홍소（TBIL）、직접담홍소（DBIL）、병안산안기전이매（ALT）균유증가，즉간공능수도손상，혈청TNF‐α표체증가，중도ICP환자교경도ICP환자상술지표승고，산후출혈솔증가，Apgar평분강저（P＜0．05）。결론 ICP계고위임신，TNF‐α화CG、TBA공동반영ICP적병정엄중정도。
Objective To investigate the influence of total bile acid (TBA) ,cholyglycine(CG) ,biochemical parameters of liv‐er ,tumor necrosis factor‐α(TNF‐α) in the patients of intrahepatic cholestasis of pregnancy (ICP) on parturients and perinatal new‐borns .Methods The clinical data in 164 cases of ICP in our hospital from January 2012 to December 2013 were retrospectively ana‐lyzed .TBA ,CG and TNF‐αwere detected by the radioimmunoassay and TBIL ,DBIL ,ALT and AST were analyzed by the biochemi‐cal analyzer .Results TBA ,CG ,TBIL ,DBIL and ALT in the patients with ICP were increased than those in normal pregnant women ,i .e .the liver function was damaged ,serum TNF‐αexpression was increased ,the above indexes in the patients with severe ICP were increased compared with the mild ICP patients ,postpartum hemorrhage volume was increased and the Apgar scores were decreased (P<0 .05) .Conclusion ICP is high risk pregnancy .TNF‐α,CG and TBA reflect the severity degree of ICP .