CAJ | 학술논문

目的：探讨普瑞巴林联合鞘内输注舒芬太尼治疗骨转移癌爆发痛的临床疗效。方法：将60例骨转移癌爆发痛患者随机分成3组：A组(普瑞巴林+鞘内输注舒芬太尼组，n=20)，B组(安慰剂+鞘内输注舒芬太尼组，n=20)和C组(口服硫酸吗啡控释片组，n=20)。采用疼痛视觉模拟评分(visual analogue scale，VAS)评估3组患者治疗后基础痛及爆发痛的强度，并观察爆发痛的发作频率、总体满意度(general satisfaction，GSS)及不良反应。结果：与B组和C组比较，A组患者的基础痛及爆发痛VAS评分和发作频率显著降低(P<0.05)，患者的GSS最高(P<0.05)，恶心呕吐、嗜睡及便秘等不良反应少。结论：普瑞巴林联合鞘内输注舒芬太尼能有效减轻骨转移癌基础痛和爆发痛。
목적：탐토보서파림연합초내수주서분태니치료골전이암폭발통적림상료효。방법：장60례골전이암폭발통환자수궤분성3조：A조(보서파림+초내수주서분태니조，n=20)，B조(안위제+초내수주서분태니조，n=20)화C조(구복류산마배공석편조，n=20)。채용동통시각모의평분(visual analogue scale，VAS)평고3조환자치료후기출통급폭발통적강도，병관찰폭발통적발작빈솔、총체만의도(general satisfaction，GSS)급불량반응。결과：여B조화C조비교，A조환자적기출통급폭발통VAS평분화발작빈솔현저강저(P<0.05)，환자적GSS최고(P<0.05)，악심구토、기수급편비등불량반응소。결론：보서파림연합초내수주서분태니능유효감경골전이암기출통화폭발통。
Objective: To evaluate the analgesic effect of pregabalin combined with intrathecal sufentanil infusion for the treatment of breakthrough pain in patients with bone metastases. Methods: A total of 60 breakthrough pain patients with bone metastases were randomly divided to 3 groups: group A (pregabalin combined with intrathecal sufentanil infusion group,n=20), group B (placebo combined with intrathecal sufentanil infusion group,n=20) and group C (oral morphine sulfate controlled-release tablet group,n=20). The differences in visual analogue scale (VAS)between background pain and breakthrough pain, the seizure frequency of breakthrough pain, general satisfaction and side effects of the 3 groups were observed. Results: hTe seizure frequency and VAS of breakthrough pain in group A decreased signiifcantly after the treatment (P<0.05) and the general satisfaction was the best among the the 3 groups (P<0.05), with less nausea and vomiting, constipation, drowsiness and fewer other side effects. Conclusion: Pregabalin combined with intrathecal sufentanil infusion can effectively relieve breakthrough pain in patients with bone metastases.