CAJ | 학술논문

目的：观察血液灌流（H P ）对尿毒症患者微炎症状态和动脉粥样硬化的影响。方法将36例尿毒症患者分为2组，每组18例，血液透析（HD）组每周透析3次，4 h／次；HP＋ HD组在HD的基础上，每周1次 HP。治疗6个月后，检测治疗前后血C反应蛋白（CRP）、总胆固醇（TC）、三酰甘油（TG）、血尿素氮（BUN）、血肌酐（Cr）的水平，超声测定颈动脉粥样斑块大小。结果与治疗前及HD组治疗后比较，HP＋ HD组治疗6个月后CRP、TG和 TC显著下降（P＜0．05），粥样斑块发生例数无增加。BUN、Cr两组差异无统计学意义（P＞0．05）。结论 HP可减轻炎性反应，减少动脉粥样硬化的发生。
목적：관찰혈액관류（H P ）대뇨독증환자미염증상태화동맥죽양경화적영향。방법장36례뇨독증환자분위2조，매조18례，혈액투석（HD）조매주투석3차，4 h／차；HP＋ HD조재HD적기출상，매주1차 HP。치료6개월후，검측치료전후혈C반응단백（CRP）、총담고순（TC）、삼선감유（TG）、혈뇨소담（BUN）、혈기항（Cr）적수평，초성측정경동맥죽양반괴대소。결과여치료전급HD조치료후비교，HP＋ HD조치료6개월후CRP、TG화 TC현저하강（P＜0．05），죽양반괴발생례수무증가。BUN、Cr량조차이무통계학의의（P＞0．05）。결론 HP가감경염성반응，감소동맥죽양경화적발생。
Objective To observe the influence of hemoperfusion(HP) on microinflammatory state and atherosclerosis in uremic patients .Methods Thirty‐six patients with uremia were randomly assigned into 2 groups ,18 cases in eath group .The hemo‐dialysis(HD) group took hemodialysis for 3 times per week ,4 h per time;the HP+ HD group took once HP per week on the basis of HD .The levels of C‐reactive protein(CRP) ,total cholesterol(TC) ,triglyceride(TG) ,urea nitrogen(BUN) and serum creatinine (Cr) were measured before therapy and in six months after therapy .The atherosclerotic plaque size was detected by ultrasound with fine resolution .Results The levels of CRP ,TG and TC after treatment in the HP+ HD group were significantly decreased com‐pared with those before treatment and the HD group (P<0 .05) .The number of therosclerotic plaques in the HP+ HD group had no increase .BUN and Cr had no statistical differences between the two groups(P>0 .05) .Conclusion HP can alleviate the inflam‐matory reaction and decrease the atherosclerosis occurrence .