CAJ | 학술논문

目的：探讨外周血 NOX2、SOD 水平与急性脑梗死的关系。方法收集98例急性脑梗死患者，采用 ELISA 法以及 WST-1还原法分别测定急性脑梗死患者患病后24 h、3 d、7 d、14 d 以及对照组 SOD、NOX2在外周血的水平，并与91例健康者进行比较。结果脑梗死组外周血 SOD 值表达于发病后24 h 内降低显著多于对照组(P <0.01)，至3~7 d 达到高峰(P <0.01)，然后在发病后14 d 逐渐升高，水平仍低于对照组，但差异无统计学意义(P >0.05)；脑梗死组 NOX2在发病后24 h 即明显升高(P <0.01)，至3~7 d 达到最高值(P <0.01)，之后又缓慢下降，至发病后14 d 接近正常。进一步将脑梗死分为轻、中、重三组，发现发病7 d 时重度、中度脑梗死组 NOX2、SOD 的水平与轻度脑梗死组、对照组比较，差异均有统计学意义(P <0.05)。结论急性脑梗死患者外周血 NOX2与 SOD 水平存在着动态变化，与脑梗死的严重程度有关，其浓度水平对急性脑梗死的病情变化及治疗具有重要的价值。
목적：탐토외주혈 NOX2、SOD 수평여급성뇌경사적관계。방법수집98례급성뇌경사환자，채용 ELISA 법이급 WST-1환원법분별측정급성뇌경사환자환병후24 h、3 d、7 d、14 d 이급대조조 SOD、NOX2재외주혈적수평，병여91례건강자진행비교。결과뇌경사조외주혈 SOD 치표체우발병후24 h 내강저현저다우대조조(P <0.01)，지3~7 d 체도고봉(P <0.01)，연후재발병후14 d 축점승고，수평잉저우대조조，단차이무통계학의의(P >0.05)；뇌경사조 NOX2재발병후24 h 즉명현승고(P <0.01)，지3~7 d 체도최고치(P <0.01)，지후우완만하강，지발병후14 d 접근정상。진일보장뇌경사분위경、중、중삼조，발현발병7 d 시중도、중도뇌경사조 NOX2、SOD 적수평여경도뇌경사조、대조조비교，차이균유통계학의의(P <0.05)。결론급성뇌경사환자외주혈 NOX2여 SOD 수평존재착동태변화，여뇌경사적엄중정도유관，기농도수평대급성뇌경사적병정변화급치료구유중요적개치。
Objective To explore the relationship of acute cerebral infarction and peripheral blood NOX2 and SOD levels. Methods Ninety-eight cases of acute cerebral infarction patients were selected as the ob-servation group,and 91 cases of healthy individuals(in physical examination)were chosen as control group.The peripheral blood NOX2 and SOD levels in patients with acute cerebral infarction and in objects of the control group were measured 24 hours,3 days,7 days,14 days after disease attack were measured by using WST-1 re-duction method and ELISA method,respectively. Results Patients of the cerebral infarction group had more significantly decreasing peripheral blood SOD expression than the control group within 24 hours(P <0.01 ), reached to the peak from day 3 to 7 (P <0.01),and elevated gradually on day 14 after disease attack,SOD lev-el of the cerebral infarction group was still lower than the control group,but there was not statistically signifi-cant difference (P > 0.05 ).The NOX2 value of cerebral infarction group increased significantly within 24 hours after disease attack (P <0.01),while the value reached the peak from day 3 to 7 (P <0.01),and then slowly declined,decreasing to near normal condition 14 days after disease attack.Cerebral infarction group was further subdivided into moderate,medium,heavy three groups.We found on day 7 of disease attack,comparison of the SOD and NOX2 levels between medium,heavy cerebral infarction groups and moderate,control groups showed statistical differences (P < 0.05 ). Conclusion There exists dynamic peripheral blood NOX2 and SOD changes in patients with acute cerebral infarction,and it's correlated with the severity of cerebral infarc-tion,its concentration plays an important role in predicting disease changes and treatment.14 days.