食品与药品
食品與藥品
식품여약품
FOOD AND DRUG
2015年
3期
166-169
,共4页
白藜芦醇%固体分散体%溶出度%差示扫描量热法%X射线衍射分析
白藜蘆醇%固體分散體%溶齣度%差示掃描量熱法%X射線衍射分析
백려호순%고체분산체%용출도%차시소묘량열법%X사선연사분석
resveratrol%solid dispersion%dissolution%DSC%XRD
目的：制备白藜芦醇-聚乙烯吡咯烷酮K-30（PVP K-30）固体分散体，并考察其体外溶出特性。方法以PVP K-30为载体，采用溶剂法制备白藜芦醇固体分散体，考察其体外溶出度。通过差示扫描量热法（DSC）和X射线衍射分析法（XRD）对固体分散体进行表征。结果固体分散体能明显促进药物的溶出，药物在15 min内溶出90%，较原料药有显著提高。DSC和XRD证实白藜芦醇以非结晶形式被包埋于PVP K-30中，形成固体分散体。结论将白藜芦醇制备成固体分散体可显著提高药物体外溶出度，且制备工艺简单，成本低廉。
目的：製備白藜蘆醇-聚乙烯吡咯烷酮K-30（PVP K-30）固體分散體，併攷察其體外溶齣特性。方法以PVP K-30為載體，採用溶劑法製備白藜蘆醇固體分散體，攷察其體外溶齣度。通過差示掃描量熱法（DSC）和X射線衍射分析法（XRD）對固體分散體進行錶徵。結果固體分散體能明顯促進藥物的溶齣，藥物在15 min內溶齣90%，較原料藥有顯著提高。DSC和XRD證實白藜蘆醇以非結晶形式被包埋于PVP K-30中，形成固體分散體。結論將白藜蘆醇製備成固體分散體可顯著提高藥物體外溶齣度，且製備工藝簡單，成本低廉。
목적：제비백려호순-취을희필각완동K-30（PVP K-30）고체분산체，병고찰기체외용출특성。방법이PVP K-30위재체，채용용제법제비백려호순고체분산체，고찰기체외용출도。통과차시소묘량열법（DSC）화X사선연사분석법（XRD）대고체분산체진행표정。결과고체분산체능명현촉진약물적용출，약물재15 min내용출90%，교원료약유현저제고。DSC화XRD증실백려호순이비결정형식피포매우PVP K-30중，형성고체분산체。결론장백려호순제비성고체분산체가현저제고약물체외용출도，차제비공예간단，성본저렴。
ObjectiveTo prepare the resveratrol-PVP K-30 solid dispersion and evaluate its in vitro dissolution characteristic.Methods The solid dispersion of resveratrol was prepared by solvent method, using PVP K-30 as carrier, and its in vitro dissolution was evaluated. The solid dispersion was characterized by differential scanning calorimetry (DSC) and X-ray diffraction analysis (XRD).Results The dissolution of resveratrol was obviously improved, 90 % of the drug dissolved within 15 min. The characterization research showed that the resveratrol was embedded in PVP K-30 amorphously and the solid dispersion was formed.Conclusion Solid dispersion can markedly improve the in vitro dissolution of resveratrol. The preparation process is uncomplicated and low cost.
