CAJ | 학술논문

梗阻性黄疸是临床上一种常见的病理生理现象,重症黄疸在积极的治疗后其病死率仍然较高.梗阻性黄疸导致患者死亡或重要器官功能损害的因素很多,其中肠道屏障破坏后引起的内毒素血症甚至脓毒症起着重要的作用.梗阻性黄疸可从多个环节损害肠黏膜屏障,其中包括免疫中断、生物和机械性肠屏障破坏.本文从肠道内胆汁缺失的方面,阐述梗阻性黄疸对肠黏膜屏障功能的破坏.
경조성황달시림상상일충상견적병리생리현상,중증황달재적겁적치료후기병사솔잉연교고.경조성황달도치환자사망혹중요기관공능손해적인소흔다,기중장도병장파배후인기적내독소혈증심지농독증기착중요적작용.경조성황달가종다개배절손해장점막병장,기중포괄면역중단、생물화궤계성장병장파배.본문종장도내담즙결실적방면,천술경조성황달대장점막병장공능적파배.
Obstructive jaundice is a common clinical pathophysiological phenomenon,severe jaundice after aggressive treatment the mortality is still high.Many factors cause the death of the patient with obstructive jaundice or vital organ dysfunction,which caused damage to the intestinal barrier after endotoxemia or sepsis plays an inportant role.Obstructive jaundice can damage the intestinal mucosal barrier from several aspects,including the immune interruption,biological and mechanical damage of the intestinal barrier.