CAJ | 학술논문

目的：研究高淀粉酶血症对重度急性有机磷农药中毒( AOPP)患者预后的影响。方法58例重度AOPP患者根据入院时血清淀粉酶水平，将患者分为对照组、轻度高淀粉酶血症组、重度高淀粉酶血症组，观察各组急性呼吸衰竭、中间综合征IMS、反跳、迟发性多神经病变的发生率及预后。结果与对照组相比，轻度、重度高淀粉酶血症组急性呼吸衰竭、中间综合征、迟发性多神经病变发生率明显升高(P<0．05)，反跳发生率差异无统计学意义(P>0．05)，治愈率降低(P<0．05)。重度高淀粉酶血症组患者的急性呼吸衰竭、IMS发生率高于轻度高淀粉酶血症组( P<0．05)，而两组患者反跳、迟发性多神经病变的发生率差异无统计学意义(P>0．05)，治愈率差异亦无统计学意义(P>0．05)。结论合并血清淀粉酶升高的重度AOPP患者各种并发症的发生率增高(反跳除外)、治愈率降低，临床上应重视对患者血清淀粉酶水平的监测。
목적：연구고정분매혈증대중도급성유궤린농약중독( AOPP)환자예후적영향。방법58례중도AOPP환자근거입원시혈청정분매수평，장환자분위대조조、경도고정분매혈증조、중도고정분매혈증조，관찰각조급성호흡쇠갈、중간종합정IMS、반도、지발성다신경병변적발생솔급예후。결과여대조조상비，경도、중도고정분매혈증조급성호흡쇠갈、중간종합정、지발성다신경병변발생솔명현승고(P<0．05)，반도발생솔차이무통계학의의(P>0．05)，치유솔강저(P<0．05)。중도고정분매혈증조환자적급성호흡쇠갈、IMS발생솔고우경도고정분매혈증조( P<0．05)，이량조환자반도、지발성다신경병변적발생솔차이무통계학의의(P>0．05)，치유솔차이역무통계학의의(P>0．05)。결론합병혈청정분매승고적중도AOPP환자각충병발증적발생솔증고(반도제외)、치유솔강저，림상상응중시대환자혈청정분매수평적감측。
Objective To study the influence of hyperamylasemia on the prognosis of patients with severe organophosphorus pesticide poisoning. Methods Fifty-eight cases of acute severe organophosphorus pesticide poisoning were analyzed retrospectively. According to the serum amylase level on admission, the patients were divided into normal control group, mild hyperamylasemia group and severe hyperamy-lasemia group. All the incidences of acute respiratory failure, intermediate syndrome, rebound, delayed polyneuropathy and the prognosis in each group were observed. Results Compared with the control group, the incidences of acute respiratory failure, intermediate syndrome, delayed polyneuropathy of mild and severe hyperamylasemia group were significantly higher ( P <0. 05 ) , but the bounce rate showed no difference (P>0. 05), and the cure rate was lower (P<0. 05). The incidences of acute respiratory failure and intermediate syndrome of se-vere hyperamylasemia group were higher than those of mild hyperamylasemia group (P<0. 05), while the rebound incidence, delayed poly-neuropathy incidence and cure rate between the two groups had no significant differences (P>0. 05). Conclusion Due to the conclusion of increased rate of complications ( except rebound) and reduced cure rate in severe organic phosphorus pesticide poisoning patients with elevat-ed serum amylase, clinical doctors should pay attention to the monitoring of serum amylase level.