安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2015年
6期
643-645
,共3页
大鼠%炎症%牙髓炎%Nav1. 7
大鼠%炎癥%牙髓炎%Nav1. 7
대서%염증%아수염%Nav1. 7
Rats%Inflammation%Pulpitis%Nav1. 7
目的:探讨大鼠炎症牙髓中钠离子通道Nav1.7的表达。方法60只SD大鼠分为正常组( A组)和炎症组,炎症组中,封脂多糖(LPS)1 d为B组、3 d为C组、5 d为D组。炎症组通过置入LPS诱导产生牙髓炎。通过HE染色观察各组大鼠牙髓组织病理学改变,通过免疫组化和ELISA检测各组大鼠牙髓中Nav1.7的表达。结果各组牙髓组织病理学发生改变,各组牙髓切片中均有Nav1.7的表达。 ELISA结果显示,4组牙髓中Nav1.7的表达量分别为(3.38±0.10)、(3.67±0.15)、(4.04±0.14)和(4.25±0.11)μg/L,各组间差异有统计学意义(P<0.05)。结论 Nav1.7的表达增高可能与牙髓炎症具有潜在关联性。
目的:探討大鼠炎癥牙髓中鈉離子通道Nav1.7的錶達。方法60隻SD大鼠分為正常組( A組)和炎癥組,炎癥組中,封脂多糖(LPS)1 d為B組、3 d為C組、5 d為D組。炎癥組通過置入LPS誘導產生牙髓炎。通過HE染色觀察各組大鼠牙髓組織病理學改變,通過免疫組化和ELISA檢測各組大鼠牙髓中Nav1.7的錶達。結果各組牙髓組織病理學髮生改變,各組牙髓切片中均有Nav1.7的錶達。 ELISA結果顯示,4組牙髓中Nav1.7的錶達量分彆為(3.38±0.10)、(3.67±0.15)、(4.04±0.14)和(4.25±0.11)μg/L,各組間差異有統計學意義(P<0.05)。結論 Nav1.7的錶達增高可能與牙髓炎癥具有潛在關聯性。
목적:탐토대서염증아수중납리자통도Nav1.7적표체。방법60지SD대서분위정상조( A조)화염증조,염증조중,봉지다당(LPS)1 d위B조、3 d위C조、5 d위D조。염증조통과치입LPS유도산생아수염。통과HE염색관찰각조대서아수조직병이학개변,통과면역조화화ELISA검측각조대서아수중Nav1.7적표체。결과각조아수조직병이학발생개변,각조아수절편중균유Nav1.7적표체。 ELISA결과현시,4조아수중Nav1.7적표체량분별위(3.38±0.10)、(3.67±0.15)、(4.04±0.14)화(4.25±0.11)μg/L,각조간차이유통계학의의(P<0.05)。결론 Nav1.7적표체증고가능여아수염증구유잠재관련성。
Objective To investigate the expression of voltage gated sodium channel Nav1. 7 in rat pulpitis. Sixty rats were randomly divided into a nontreatment group(A)and three inflammation groups:day1(B), day3(C) and day5(D), and pulpitis was induced by crea-ting pulp exposures to LPS in rat incisions. Histopathological changes and the expression of Nav1. 7 were observed by Hematoxylin-eosin stai-ning, immunohistochemistry and ELISA(Enzyme-linked immunosorbent assay) in each team. Results Histopathological changes were re-vealed in each team, while Nav1. 7 was also expressed. ELISA results revealed that the level of Nav1. 7 in control pulp tissue was (3. 38 ± 0. 10) μg/L, in painful pulp tissue of 1d group was(3. 67 ± 0. 15)μg/L, in painful pulp tissue of 3d group was(4. 04 ± 0. 14)μg/L and in painful pulp tissue of 5d group was(4. 25 ± 0. 11)μg/L(P<0. 05). Conclusion The relationship between dental pain and Nav1. 7 expres-sion level maybe exist.