CAJ | 학술논문

代谢组学能定量分析生物体细胞、组织及血、尿、唾液等生物样品中的内源性小分子代谢物（相对分子质量＜1000）。其主要技术平台包括核磁共振技术、液相-质谱联用技术、气相色谱-质谱联用技术以及其他光谱技术等。代谢组学在研究哮喘的发病机制、早期诊断、病理生理学研究、新药研发及药物疗效监测方面有许多研究。该文综合论述了代谢组学在哮喘的研究进展，以期为哮喘的发病机制、早期诊断、治疗提供新方向。
대사조학능정량분석생물체세포、조직급혈、뇨、타액등생물양품중적내원성소분자대사물（상대분자질량＜1000）。기주요기술평태포괄핵자공진기술、액상-질보련용기술、기상색보-질보련용기술이급기타광보기술등。대사조학재연구효천적발병궤제、조기진단、병리생이학연구、신약연발급약물료효감측방면유허다연구。해문종합논술료대사조학재효천적연구진전，이기위효천적발병궤제、조기진단、치료제공신방향。
Metabolomics is commonly known as a quantitative analysis of all endogenous low-molecular-weight components (relative molecular mass <1 000)in a biological sample,such as cells,tissue,plasma, urine or saliva of organisms.The main techniques of metabolomics include nuclear magnetic resonance, liquid phase-mass spectrometry and gas chromatography-mass spectrometry, etc.Many studies on the applications of metabolomics in asthma have reported, including in the filed of pathogenesis, pathophysiology,early diagnosis and therapeutic effects monitoring.The progress of metabolomics in the research filed of asthma was review in this article,providing a new direction for the studies on pathogenesis, early diagnosis and treatment of asthma.